Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2

Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2

Autosomal recessive form of hyper-IgM syndrome type 2 (AR-HIGM2) is secondary to mutations affecting both alleles of AICDA gene encoding activation-induced cytidine deaminase, characterized by defects of immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM) in most of the p...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 115(2005), 3 vom: 31. Juni, Seite 277-85
1. Verfasser: Imai, Kohsuke (VerfasserIn)
Weitere Verfasser: Zhu, Yi, Revy, Patrick, Morio, Tomohiro, Mizutani, Shuki, Fischer, Alain, Nonoyama, Shigeaki, Durandy, Anne
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Immunoglobulin M AICDA (Activation-Induced Cytidine Deaminase) EC 3.5.4.- Cytosine Deaminase EC 3.5.4.1 Cytidine Deaminase EC 3.5.4.5 DNA Repair Enzymes EC 6.5.1.-