Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2
Autosomal recessive form of hyper-IgM syndrome type 2 (AR-HIGM2) is secondary to mutations affecting both alleles of AICDA gene encoding activation-induced cytidine deaminase, characterized by defects of immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM) in most of the p...
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 115(2005), 3 vom: 31. Juni, Seite 277-85 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , , |
| Format: | Article |
| Langue: | English |
| Publié: |
2005
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| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Journal Article Research Support, Non-U.S. Gov't Immunoglobulin M AICDA (Activation-Induced Cytidine Deaminase) EC 3.5.4.- Cytosine Deaminase EC 3.5.4.1 Cytidine Deaminase EC 3.5.4.5 DNA Repair Enzymes |