Pathogenic role and diagnostic utility of interferon-α in histiocytic necrotizing lymphadenitis

Pathogenic role and diagnostic utility of interferon-α in histiocytic necrotizing lymphadenitis

Copyright © 2024. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 266(2024) vom: 15. Aug., Seite 110324
1. Verfasser: Kaneko, Shuya (VerfasserIn)
Weitere Verfasser: Shimbo, Asami, Irabu, Hitoshi, Hatano, Maho, Takasawa, Kei, Kamiya, Takahiro, Akamine, Keiji, Tanaka, Takayuki, Minato, Toshinori, Ono, Makoto, Yokoyama, Koji, Arisaka, Atsuko, Yasumi, Takahiro, Ueno, Kazuyuki, Fujita, Shuhei, Tanaka, Yumi, Hayashi, Daisuke, Nishikawa, Hiroki, Fujita, Yuji, Yuza, Yuki, Mori, Masaaki, Morio, Tomohiro, Shimizu, Masaki
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Histiocytic necrotizing lymphadenitis Interferon stimulated gene Interferon-α Kikuchi–Fujimoto disease Plasmacytoid dendritic cell Subacute necrotizing lymphadenitis Interferon-alpha Myxovirus Resistance Proteins MX1 protein, human mehr... Biomarkers Cytokines
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500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2024. Published by Elsevier Inc. 
520 |a PURPOSE: Histiocytic necrotizing lymphadenitis (HNL) is an inflammatory disease of unknown etiology clinically characterized by painful lymphadenopathy. This study aimed to investigate the role of interferon (IFN)-α in the pathogenesis of HNL and the clinical significance of serum IFN-α levels for the diagnosis and monitoring of HNL disease activity 
520 |a METHODS: This study enrolled 47 patients with HNL and 43 patients with other inflammatory diseases that require HNL differentiation including malignant lymphoma (ML), bacterial lymphadenitis, and Kawasaki disease. Expression of IFN-stimulated genes (ISGs) and MX1 in the lymph nodes was measured by real-time quantitative reverse transcription polymerase chain reaction and immunofluorescence staining, respectively. Enzyme-linked immunosorbent assay was used to quantify serum cytokine levels. The results were compared with the clinical features and disease course of HNL 
520 |a RESULTS: Patients with HNL had a significantly elevated ISG expression in the lymph nodes compared with those with ML. MX1 and CD123, a specific marker of plasmacytoid dendritic cells (pDCs), were colocalized. In patients with HNL, serum IFN-α levels were significantly elevated and positively correlated with disease activity. The serum IFN-α level cutoff value for differentiating HNL from other diseases was 11.5 pg/mL 
520 |a CONCLUSION: IFN-α overproduction from pDCs may play a critical role in HNL pathogenesis. The serum IFN-α level may be a valuable biomarker for the diagnosis and monitoring of disease activity in patients with HNL 
650 4 |a Journal Article 
650 4 |a Histiocytic necrotizing lymphadenitis 
650 4 |a Interferon stimulated gene 
650 4 |a Interferon-α 
650 4 |a Kikuchi–Fujimoto disease 
650 4 |a Plasmacytoid dendritic cell 
650 4 |a Subacute necrotizing lymphadenitis 
650 7 |a Interferon-alpha  |2 NLM 
650 7 |a Myxovirus Resistance Proteins  |2 NLM 
650 7 |a MX1 protein, human  |2 NLM 
650 7 |a Biomarkers  |2 NLM 
650 7 |a Cytokines  |2 NLM 
700 1 |a Shimbo, Asami  |e verfasserin  |4 aut 
700 1 |a Irabu, Hitoshi  |e verfasserin  |4 aut 
700 1 |a Hatano, Maho  |e verfasserin  |4 aut 
700 1 |a Takasawa, Kei  |e verfasserin  |4 aut 
700 1 |a Kamiya, Takahiro  |e verfasserin  |4 aut 
700 1 |a Akamine, Keiji  |e verfasserin  |4 aut 
700 1 |a Tanaka, Takayuki  |e verfasserin  |4 aut 
700 1 |a Minato, Toshinori  |e verfasserin  |4 aut 
700 1 |a Ono, Makoto  |e verfasserin  |4 aut 
700 1 |a Yokoyama, Koji  |e verfasserin  |4 aut 
700 1 |a Arisaka, Atsuko  |e verfasserin  |4 aut 
700 1 |a Yasumi, Takahiro  |e verfasserin  |4 aut 
700 1 |a Ueno, Kazuyuki  |e verfasserin  |4 aut 
700 1 |a Fujita, Shuhei  |e verfasserin  |4 aut 
700 1 |a Tanaka, Yumi  |e verfasserin  |4 aut 
700 1 |a Hayashi, Daisuke  |e verfasserin  |4 aut 
700 1 |a Nishikawa, Hiroki  |e verfasserin  |4 aut 
700 1 |a Fujita, Yuji  |e verfasserin  |4 aut 
700 1 |a Yuza, Yuki  |e verfasserin  |4 aut 
700 1 |a Mori, Masaaki  |e verfasserin  |4 aut 
700 1 |a Morio, Tomohiro  |e verfasserin  |4 aut 
700 1 |a Shimizu, Masaki  |e verfasserin  |4 aut 
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