Pathogenic role and diagnostic utility of interferon-α in histiocytic necrotizing lymphadenitis

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 266(2024) vom: 15. Aug., Seite 110324
1. Verfasser:	Kaneko, Shuya (VerfasserIn)
Weitere Verfasser:	Shimbo, Asami, Irabu, Hitoshi, Hatano, Maho, Takasawa, Kei, Kamiya, Takahiro, Akamine, Keiji, Tanaka, Takayuki, Minato, Toshinori, Ono, Makoto, Yokoyama, Koji, Arisaka, Atsuko, Yasumi, Takahiro, Ueno, Kazuyuki, Fujita, Shuhei, Tanaka, Yumi, Hayashi, Daisuke, Nishikawa, Hiroki, Fujita, Yuji, Yuza, Yuki, Mori, Masaaki, Morio, Tomohiro, Shimizu, Masaki
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2024
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Histiocytic necrotizing lymphadenitis Interferon stimulated gene Interferon-α Kikuchi–Fujimoto disease Plasmacytoid dendritic cell Subacute necrotizing lymphadenitis Interferon-alpha Myxovirus Resistance Proteins MX1 protein, human mehr... Biomarkers Cytokines

Beschreibung
Zusammenfassung:	Copyright © 2024. Published by Elsevier Inc. PURPOSE: Histiocytic necrotizing lymphadenitis (HNL) is an inflammatory disease of unknown etiology clinically characterized by painful lymphadenopathy. This study aimed to investigate the role of interferon (IFN)-α in the pathogenesis of HNL and the clinical significance of serum IFN-α levels for the diagnosis and monitoring of HNL disease activity METHODS: This study enrolled 47 patients with HNL and 43 patients with other inflammatory diseases that require HNL differentiation including malignant lymphoma (ML), bacterial lymphadenitis, and Kawasaki disease. Expression of IFN-stimulated genes (ISGs) and MX1 in the lymph nodes was measured by real-time quantitative reverse transcription polymerase chain reaction and immunofluorescence staining, respectively. Enzyme-linked immunosorbent assay was used to quantify serum cytokine levels. The results were compared with the clinical features and disease course of HNL RESULTS: Patients with HNL had a significantly elevated ISG expression in the lymph nodes compared with those with ML. MX1 and CD123, a specific marker of plasmacytoid dendritic cells (pDCs), were colocalized. In patients with HNL, serum IFN-α levels were significantly elevated and positively correlated with disease activity. The serum IFN-α level cutoff value for differentiating HNL from other diseases was 11.5 pg/mL CONCLUSION: IFN-α overproduction from pDCs may play a critical role in HNL pathogenesis. The serum IFN-α level may be a valuable biomarker for the diagnosis and monitoring of disease activity in patients with HNL
Beschreibung:	Date Completed 16.08.2024 Date Revised 22.08.2024 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2024.110324