Immunophenotyping of A20 haploinsufficiency by multicolor flow cytometry

Immunophenotyping of A20 haploinsufficiency by multicolor flow cytometry

Copyright © 2020 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 216(2020) vom: 05. Juli, Seite 108441
1. Verfasser: Kadowaki, Tomonori (VerfasserIn)
Weitere Verfasser: Ohnishi, Hidenori, Kawamoto, Norio, Kadowaki, Saori, Hori, Tomohiro, Nishimura, Kenichi, Kobayashi, Chie, Shigemura, Tomonari, Ogata, Shohei, Inoue, Yuzaburo, Hiejima, Eitaro, Izawa, Kazushi, Matsubayashi, Tadashi, Matsumoto, Kazuaki, Imai, Kohsuke, Nishikomori, Ryuta, Ito, Shuichi, Kanegane, Hirokazu, Fukao, Toshiyuki
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Autoimmunity Double-negative T cell Follicular helper T cell Haploinsufficiency of A20 Regulatory T cell TNFAIP3
LEADER 01000naa a22002652 4500
001 NLM309193931
003 DE-627
005 20231225133355.0
007 cr uuu---uuuuu
008 231225s2020 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.clim.2020.108441  |2 doi 
028 5 2 |a pubmed24n1030.xml 
035 |a (DE-627)NLM309193931 
035 |a (NLM)32335289 
035 |a (PII)S1521-6616(19)30712-0 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Kadowaki, Tomonori  |e verfasserin  |4 aut 
245 1 0 |a Immunophenotyping of A20 haploinsufficiency by multicolor flow cytometry 
264 1 |c 2020 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 01.02.2021 
500 |a Date Revised 01.02.2021 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2020 Elsevier Inc. All rights reserved. 
520 |a Haploinsufficiency of A20 (HA20) causes inflammatory disease resembling Behçet's disease; many cases have been reported, including some that are complicated with autoimmune diseases. This study aims to clarify the immunophenotype of patients with HA20 by analyzing lymphocyte subsets using multicolor flow cytometry. The patients with HA20 previously diagnosed in a nationwide survey were compared by their cell subpopulations. In total, 27 parameters including regulatory T cells (Tregs), double-negative T cells (DNTs), and follicular helper T cells (TFHs) were analyzed and compared with the reference values in four age groups: 0-1, 2-6, 7-19, and ≥20 years. The Tregs of patients with HA20 tended to increase in tandem with age-matched controls at all ages. In addition, patients ≥20 years had increased DNTs compared with controls, whereas TFHs significantly increased in younger patients. In HA20 patients, the increase in DNTs and TFHs may contribute to the development of autoimmune diseases 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Autoimmunity 
650 4 |a Double-negative T cell 
650 4 |a Follicular helper T cell 
650 4 |a Haploinsufficiency of A20 
650 4 |a Regulatory T cell 
650 4 |a TNFAIP3 
700 1 |a Ohnishi, Hidenori  |e verfasserin  |4 aut 
700 1 |a Kawamoto, Norio  |e verfasserin  |4 aut 
700 1 |a Kadowaki, Saori  |e verfasserin  |4 aut 
700 1 |a Hori, Tomohiro  |e verfasserin  |4 aut 
700 1 |a Nishimura, Kenichi  |e verfasserin  |4 aut 
700 1 |a Kobayashi, Chie  |e verfasserin  |4 aut 
700 1 |a Shigemura, Tomonari  |e verfasserin  |4 aut 
700 1 |a Ogata, Shohei  |e verfasserin  |4 aut 
700 1 |a Inoue, Yuzaburo  |e verfasserin  |4 aut 
700 1 |a Hiejima, Eitaro  |e verfasserin  |4 aut 
700 1 |a Izawa, Kazushi  |e verfasserin  |4 aut 
700 1 |a Matsubayashi, Tadashi  |e verfasserin  |4 aut 
700 1 |a Matsumoto, Kazuaki  |e verfasserin  |4 aut 
700 1 |a Imai, Kohsuke  |e verfasserin  |4 aut 
700 1 |a Nishikomori, Ryuta  |e verfasserin  |4 aut 
700 1 |a Ito, Shuichi  |e verfasserin  |4 aut 
700 1 |a Kanegane, Hirokazu  |e verfasserin  |4 aut 
700 1 |a Fukao, Toshiyuki  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 216(2020) vom: 05. Juli, Seite 108441  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:216  |g year:2020  |g day:05  |g month:07  |g pages:108441 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2020.108441  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_11 
912 |a GBV_ILN_24 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 216  |j 2020  |b 05  |c 07  |h 108441