Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment

Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment

Human hematopoietic prostaglandin synthase, one of the better therapeutic target enzymes for allergy and inflammation, was crystallized with 22 inhibitors and in three inhibitor-free conditions in microgravity. Most of the space-grown crystals showed better X-ray diffraction patterns than the terres...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Journal of synchrotron radiation. - 1994. - 18(2011), 1 vom: 28. Jan., Seite 88-91
1. Verfasser: Tanaka, Hiroaki (VerfasserIn)
Weitere Verfasser: Tsurumura, Toshiharu, Aritake, Kosuke, Furubayashi, Naoki, Takahashi, Sachiko, Yamanaka, Mari, Hirota, Erika, Sano, Satoshi, Sato, Masaru, Kobayashi, Tomoyuki, Tanaka, Tetsuo, Inaka, Koji, Urade, Yoshihiro
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:Journal of synchrotron radiation
Schlagworte:Journal Article Research Support, Non-U.S. Gov't 4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine Lipocalins Piperidines Intramolecular Oxidoreductases EC 5.3.- prostaglandin R2 D-isomerase EC 5.3.99.2
LEADER 01000naa a22002652 4500
001 NLM204461405
003 DE-627
005 20231223232057.0
007 cr uuu---uuuuu
008 231223s2011 xx |||||o 00| ||eng c
024 7 |a 10.1107/S0909049510037076  |2 doi 
028 5 2 |a pubmed24n0682.xml 
035 |a (DE-627)NLM204461405 
035 |a (NLM)21169700 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Tanaka, Hiroaki  |e verfasserin  |4 aut 
245 1 0 |a Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment 
264 1 |c 2011 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 04.04.2011 
500 |a Date Revised 20.10.2021 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Human hematopoietic prostaglandin synthase, one of the better therapeutic target enzymes for allergy and inflammation, was crystallized with 22 inhibitors and in three inhibitor-free conditions in microgravity. Most of the space-grown crystals showed better X-ray diffraction patterns than the terrestrially grown ones, indicating the advantage of a microgravity environment on protein crystallization, especially in the case of this protein 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 7 |a 4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine  |2 NLM 
650 7 |a Lipocalins  |2 NLM 
650 7 |a Piperidines  |2 NLM 
650 7 |a Intramolecular Oxidoreductases  |2 NLM 
650 7 |a EC 5.3.-  |2 NLM 
650 7 |a prostaglandin R2 D-isomerase  |2 NLM 
650 7 |a EC 5.3.99.2  |2 NLM 
700 1 |a Tsurumura, Toshiharu  |e verfasserin  |4 aut 
700 1 |a Aritake, Kosuke  |e verfasserin  |4 aut 
700 1 |a Furubayashi, Naoki  |e verfasserin  |4 aut 
700 1 |a Takahashi, Sachiko  |e verfasserin  |4 aut 
700 1 |a Yamanaka, Mari  |e verfasserin  |4 aut 
700 1 |a Hirota, Erika  |e verfasserin  |4 aut 
700 1 |a Sano, Satoshi  |e verfasserin  |4 aut 
700 1 |a Sato, Masaru  |e verfasserin  |4 aut 
700 1 |a Kobayashi, Tomoyuki  |e verfasserin  |4 aut 
700 1 |a Tanaka, Tetsuo  |e verfasserin  |4 aut 
700 1 |a Inaka, Koji  |e verfasserin  |4 aut 
700 1 |a Urade, Yoshihiro  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Journal of synchrotron radiation  |d 1994  |g 18(2011), 1 vom: 28. Jan., Seite 88-91  |w (DE-627)NLM09824129X  |x 1600-5775  |7 nnns 
773 1 8 |g volume:18  |g year:2011  |g number:1  |g day:28  |g month:01  |g pages:88-91 
856 4 0 |u http://dx.doi.org/10.1107/S0909049510037076  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_40 
912 |a GBV_ILN_350 
912 |a GBV_ILN_2005 
951 |a AR 
952 |d 18  |j 2011  |e 1  |b 28  |c 01  |h 88-91