Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment
Human hematopoietic prostaglandin synthase, one of the better therapeutic target enzymes for allergy and inflammation, was crystallized with 22 inhibitors and in three inhibitor-free conditions in microgravity. Most of the space-grown crystals showed better X-ray diffraction patterns than the terres...
| Veröffentlicht in: | Journal of synchrotron radiation. - 1994. - 18(2011), 1 vom: 28. Jan., Seite 88-91 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , , , , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2011
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| Zugriff auf das übergeordnete Werk: | Journal of synchrotron radiation |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't 4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine Lipocalins Piperidines Intramolecular Oxidoreductases EC 5.3.- prostaglandin R2 D-isomerase EC 5.3.99.2 |
| Zusammenfassung: | Human hematopoietic prostaglandin synthase, one of the better therapeutic target enzymes for allergy and inflammation, was crystallized with 22 inhibitors and in three inhibitor-free conditions in microgravity. Most of the space-grown crystals showed better X-ray diffraction patterns than the terrestrially grown ones, indicating the advantage of a microgravity environment on protein crystallization, especially in the case of this protein |
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| Beschreibung: | Date Completed 04.04.2011 Date Revised 20.10.2021 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1600-5775 |
| DOI: | 10.1107/S0909049510037076 |