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NLM191794686 |
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DE-627 |
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20231223191833.0 |
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cr uuu---uuuuu |
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231223s2009 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2009.09.004
|2 doi
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| 028 |
5 |
2 |
|a pubmed24n0639.xml
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|a (DE-627)NLM191794686
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| 035 |
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|a (NLM)19800850
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Arikawa, Tomohiro
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages
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| 264 |
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 22.12.2009
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| 500 |
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|a Date Revised 09.11.2009
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Galectin-9 up-regulated Fc gamma RIIb expression of mouse peritoneal macrophages in vitro but down-regulated Fc gamma RIII expression. Galectin-9-treated macrophages stimulated with immune complexes (IC) produced less TNFalpha and IL-1 beta but more IL-10 than PBS-treated macrophages. Macrophage enhancing effects on IC-induced C5a and neutrophil chemotactic activity were also diminished for galectin-9-treated macrophages. In galectin-9-treated mice, the severity of IC-induced arthritis was reduced, as were pro-inflammatory cytokine levels in inflamed joints and serum C5a. Fc gamma RIIb expression of macrophages from galectin-9-treated mice was up-regulated, whereas Fc gamma RIII expression was down-regulated. Macrophages from galectin-9-treated mice produced less TNFalpha and IL-1 beta but more IL-10 than PBS-treated mice. Disease severity of galectin-9-transgenic mice was milder than wild-type mice, whereas that of galectin-9-deficient mice was exaggerated. Furthermore, macrophage Fc gamma RIIb expression in galectin-9-deficient mice was down-regulated, while Fc gamma RIII expression was up-regulated. These results suggest that galectin-9 suppresses IC-induced inflammation partly by regulating Fc gamma R expression on macrophages
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antigen-Antibody Complex
|2 NLM
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| 650 |
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7 |
|a Cytokines
|2 NLM
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| 650 |
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7 |
|a Fc gamma receptor IIB
|2 NLM
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| 650 |
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7 |
|a Galectins
|2 NLM
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| 650 |
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7 |
|a RNA, Messenger
|2 NLM
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| 650 |
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7 |
|a Receptors, IgG
|2 NLM
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| 650 |
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7 |
|a galectin 9, mouse
|2 NLM
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| 700 |
1 |
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|a Watanabe, Kota
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Seki, Masako
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Matsukawa, Akihiro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Oomizu, Souichi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sakata, Ken-mei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sakata, Atsuko
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ueno, Masaki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Saita, Naoki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Niki, Toshiro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yamauchi, Akira
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hirashima, Mitsuomi
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 133(2009), 3 vom: 09. Dez., Seite 382-92
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:133
|g year:2009
|g number:3
|g day:09
|g month:12
|g pages:382-92
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2009.09.004
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 133
|j 2009
|e 3
|b 09
|c 12
|h 382-92
|