Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages

Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages

Galectin-9 up-regulated Fc gamma RIIb expression of mouse peritoneal macrophages in vitro but down-regulated Fc gamma RIII expression. Galectin-9-treated macrophages stimulated with immune complexes (IC) produced less TNFalpha and IL-1 beta but more IL-10 than PBS-treated macrophages. Macrophage enh...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 133(2009), 3 vom: 09. Dez., Seite 382-92
1. Verfasser: Arikawa, Tomohiro (VerfasserIn)
Weitere Verfasser: Watanabe, Kota, Seki, Masako, Matsukawa, Akihiro, Oomizu, Souichi, Sakata, Ken-mei, Sakata, Atsuko, Ueno, Masaki, Saita, Naoki, Niki, Toshiro, Yamauchi, Akira, Hirashima, Mitsuomi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigen-Antibody Complex Cytokines Fc gamma receptor IIB Galectins RNA, Messenger Receptors, IgG galectin 9, mouse
Beschreibung
Zusammenfassung:Galectin-9 up-regulated Fc gamma RIIb expression of mouse peritoneal macrophages in vitro but down-regulated Fc gamma RIII expression. Galectin-9-treated macrophages stimulated with immune complexes (IC) produced less TNFalpha and IL-1 beta but more IL-10 than PBS-treated macrophages. Macrophage enhancing effects on IC-induced C5a and neutrophil chemotactic activity were also diminished for galectin-9-treated macrophages. In galectin-9-treated mice, the severity of IC-induced arthritis was reduced, as were pro-inflammatory cytokine levels in inflamed joints and serum C5a. Fc gamma RIIb expression of macrophages from galectin-9-treated mice was up-regulated, whereas Fc gamma RIII expression was down-regulated. Macrophages from galectin-9-treated mice produced less TNFalpha and IL-1 beta but more IL-10 than PBS-treated mice. Disease severity of galectin-9-transgenic mice was milder than wild-type mice, whereas that of galectin-9-deficient mice was exaggerated. Furthermore, macrophage Fc gamma RIIb expression in galectin-9-deficient mice was down-regulated, while Fc gamma RIII expression was up-regulated. These results suggest that galectin-9 suppresses IC-induced inflammation partly by regulating Fc gamma R expression on macrophages
Beschreibung:Date Completed 22.12.2009
Date Revised 09.11.2009
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2009.09.004