Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization : Relationship to expression of Syk and SHIP-2

Recently, signaling changes in the FcvarepsilonRI pathway involving inositol lipid phosphatases have been identified in the basophils of chronic idiopathic urticaria (CIU) subjects. Based on the profile of basophil FcvarepsilonRI-mediated histamine degranulation, we have segregated CIU subjects into...

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Publié dans:	Clinical immunology (Orlando, Fla.). - 1999. - 132(2009), 3 vom: 01. Sept., Seite 342-8
Auteur principal:	Saini, Sarbjit S (Auteur)
Autres auteurs:	Paterniti, Miya, Vasagar, Kavitha, Gibbons, Scott P Jr, Sterba, Patricia M, Vonakis, Becky M
Format:	Article en ligne
Langue:	English
Publié:	2009
Accès à la collection:	Clinical immunology (Orlando, Fla.)
Sujets:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Antibodies Intracellular Signaling Peptides and Proteins Receptors, IgE Immunoglobulin E 37341-29-0 Histamine 820484N8I3 plus... Protein-Tyrosine Kinases EC 2.7.10.1 Proto-Oncogene Proteins c-kit SYK protein, human EC 2.7.10.2 Syk Kinase Phosphoric Monoester Hydrolases EC 3.1.3.2 Inositol Polyphosphate 5-Phosphatases EC 3.1.3.56 INPP5D protein, human EC 3.1.3.86 INPPL1 protein, human Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases