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20231223175035.0 |
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231223s2009 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2009.01.015
|2 doi
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|a pubmed24n0623.xml
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|a (DE-627)NLM186923694
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|a (NLM)19269255
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Chen, Rong-Fu
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Combination of CTLA-4 and TGFbeta1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak
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| 264 |
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 09.06.2009
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The pathogenesis of dengue hemorrhagic fever (DHF) has been considered to be massive immune activation of T cells. Abnormal expression of the immune regulatory molecules, CTLA-4 and TGFbeta1, leads to disturbances of regulatory T cell immune response. We investigate the contribution of CTLA-4 and TGFbeta1 in DHF by analyzing them for association with virus load in blood and polymorphisms of CTLA-4 +49A/G, and TGFbeta1 -509C/T in a DEN-2 outbreak. The increased frequency of the TGFbeta1 -509 CC genotype in patients with DHF was compared to those with dengue fever (OR=1.9, p=0.034). Moreover, the presence of the CTLA-4 +49 G allele and TGFbeta1 -509 CC genotype increased the susceptibility to risk of DHF (OR=2.1, p=0.028) and significantly higher virus load (p=0.013). This finding suggests that a combination of CTLA-4 and TGFbeta1 polymorphisms is associated with the susceptibility of DHF and higher virus load
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| 650 |
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|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antigens, CD
|2 NLM
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| 650 |
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7 |
|a CTLA-4 Antigen
|2 NLM
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| 650 |
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7 |
|a CTLA4 protein, human
|2 NLM
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| 650 |
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7 |
|a Transforming Growth Factor beta1
|2 NLM
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| 700 |
1 |
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|a Wang, Lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Jiin-Tsuey
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chuang, Hau
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chang, Jen-Chieh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Jien-Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, I-Chun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Kuender D
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 131(2009), 3 vom: 01. Juni, Seite 404-9
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:131
|g year:2009
|g number:3
|g day:01
|g month:06
|g pages:404-9
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2009.01.015
|3 Volltext
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|d 131
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|h 404-9
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