Combination of CTLA-4 and TGFbeta1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak

The pathogenesis of dengue hemorrhagic fever (DHF) has been considered to be massive immune activation of T cells. Abnormal expression of the immune regulatory molecules, CTLA-4 and TGFbeta1, leads to disturbances of regulatory T cell immune response. We investigate the contribution of CTLA-4 and TG...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 131(2009), 3 vom: 01. Juni, Seite 404-9
1. Verfasser: Chen, Rong-Fu (VerfasserIn)
Weitere Verfasser: Wang, Lin, Cheng, Jiin-Tsuey, Chuang, Hau, Chang, Jen-Chieh, Liu, Jien-Wei, Lin, I-Chun, Yang, Kuender D
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigens, CD CTLA-4 Antigen CTLA4 protein, human Transforming Growth Factor beta1