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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.01.018
|2 doi
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|a pubmed24n0595.xml
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|a (DE-627)NLM178422908
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|a (NLM)18359275
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Hirai, Hiroki
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes
|b VAMP2 and NPY are new minor autoantigens
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|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 07.07.2008
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The four major autoantigens (IA-2, IA-2 beta, GAD65 and insulin) of type 1 diabetes are all associated with dense core or synaptic vesicles. This raised the possibility that other secretory vesicle-associated proteins might be targets of the autoimmune response in type 1 diabetes. To test this hypothesis 56 proteins, two-thirds of which are associated with secretory vesicles, were prepared by in vitro transcription/translation and screened for autoantibodies by liquid phase radioimmunoprecipitation. Two secretory vesicle-associated proteins, VAMP2 and NPY, were identified as new minor autoantigens with 21% and 9%, respectively, of 200 type 1 diabetes sera reacting positively. These findings add support to the hypothesis that secretory vesicle-associated proteins are particularly important, but not the exclusive, targets of the autoimmune response in type 1 diabetes. Selective screening of the human proteome offers a useful approach for identifying new autoantigens in autoimmune diseases
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|a Journal Article
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|a Research Support, N.I.H., Intramural
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| 650 |
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|a Autoantibodies
|2 NLM
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| 650 |
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|a Autoantigens
|2 NLM
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| 650 |
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|a Neuropeptide Y
|2 NLM
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| 650 |
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|a Vesicle-Associated Membrane Protein 2
|2 NLM
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| 700 |
1 |
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|a Miura, Junnosuke
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Yafang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Larsson, Helena
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Larsson, Karin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lernmark, Ake
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ivarsson, Sten-A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Tianxia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kingman, Albert
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tzioufas, Athanasios G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Notkins, Abner L
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 127(2008), 3 vom: 29. Juni, Seite 366-74
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:127
|g year:2008
|g number:3
|g day:29
|g month:06
|g pages:366-74
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2008.01.018
|3 Volltext
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|d 127
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