Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes : VAMP2 and NPY are new minor autoantigens

The four major autoantigens (IA-2, IA-2 beta, GAD65 and insulin) of type 1 diabetes are all associated with dense core or synaptic vesicles. This raised the possibility that other secretory vesicle-associated proteins might be targets of the autoimmune response in type 1 diabetes. To test this hypot...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 127(2008), 3 vom: 29. Juni, Seite 366-74
1. Verfasser: Hirai, Hiroki (VerfasserIn)
Weitere Verfasser: Miura, Junnosuke, Hu, Yafang, Larsson, Helena, Larsson, Karin, Lernmark, Ake, Ivarsson, Sten-A, Wu, Tianxia, Kingman, Albert, Tzioufas, Athanasios G, Notkins, Abner L
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Intramural Autoantibodies Autoantigens Neuropeptide Y Vesicle-Associated Membrane Protein 2