Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia

Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia

Bruton's tyrosine kinase (BTK), which is defective in patients with X-linked agammaglobulinemia (XLA), is expressed not only in B cells but also in monocytes and dendritic cells (DCs). DCs play a crucial role in the innate immune response against infections by sensing pathogens through Toll-lik...

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Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 126(2008), 2 vom: 12. Feb., Seite 148-54
Auteur principal: Taneichi, Hiromichi (Auteur)
Autres auteurs: Kanegane, Hirokazu, Sira, Mostafa Mohamed, Futatani, Takeshi, Agematsu, Kazunaga, Sako, Masahiro, Kaneko, Hideo, Kondo, Naomi, Kaisho, Tsuneyasu, Miyawaki, Toshio
Format: Article
Langue:English
Publié: 2008
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't Antigens, CD Cytokines Immunoglobulins Ligands Membrane Glycoproteins Toll-Like Receptors Protein-Tyrosine Kinases EC 2.7.10.1 plus... Agammaglobulinaemia Tyrosine Kinase EC 2.7.10.2 BTK protein, human