Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia

Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia

Bruton's tyrosine kinase (BTK), which is defective in patients with X-linked agammaglobulinemia (XLA), is expressed not only in B cells but also in monocytes and dendritic cells (DCs). DCs play a crucial role in the innate immune response against infections by sensing pathogens through Toll-lik...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 126(2008), 2 vom: 15. Feb., Seite 148-54
1. Verfasser: Taneichi, Hiromichi (VerfasserIn)
Weitere Verfasser: Kanegane, Hirokazu, Sira, Mostafa Mohamed, Futatani, Takeshi, Agematsu, Kazunaga, Sako, Masahiro, Kaneko, Hideo, Kondo, Naomi, Kaisho, Tsuneyasu, Miyawaki, Toshio
Format: Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigens, CD Cytokines Immunoglobulins Ligands Membrane Glycoproteins Toll-Like Receptors Protein-Tyrosine Kinases EC 2.7.10.1 mehr... Agammaglobulinaemia Tyrosine Kinase EC 2.7.10.2 BTK protein, human