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NLM168189895 |
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20231223114558.0 |
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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed24n0561.xml
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|a (DE-627)NLM168189895
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|a (NLM)17276735
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Taieb, Aurele
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Intrinsic ability of GM+IL-4 but not Flt3L-induced rat dendritic cells to promote allogeneic T cell hyporesponsiveness
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 26.06.2007
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|a Date Revised 03.12.2007
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The influence of GM+IL-4 and Flt3 ligand (FL) on phenotype and function of BM-derived DC from Lewis rats was investigated. GM+IL-4-induced DC, despite expression of CD80/CD86, were less stimulatory than FL-induced DC that expressed low CD80/CD86 and were efficient stimulators of allogeneic T cells. GM+IL-4 DC were CD11b+ OX62lo, whereas FL DC were CD11blo OX62+. Following activation, GM+IL-4 DC produced IL-10 and IL-6, but no IL-12p70, and were resistant to further maturation. FL DC produced IL-12p70, IFN-alpha/beta, IL-10 and IL-6 and underwent maturation. Repeated stimulation of T cells with GM+IL-4 DC inhibited proliferation, cytokine production and induced early T cell apoptosis. FL DC-activated T cells produced large amounts of IFN-gamma/IL-10 and exhibited late T cell apoptosis/necrosis. In vivo, GM+IL-4 DC induced alloAg-specific hyporesponsiveness following T cell restimulation. These results demonstrate that GM+IL-4 DC display intrinsic regulatory properties, inducing passive-cell-death in T cells with potential for inactivation/regulation of alloreactive T cells in transplantation
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| 650 |
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Antibodies, Monoclonal
|2 NLM
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|a Antigens, CD
|2 NLM
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|a Dinucleoside Phosphates
|2 NLM
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|a Histocompatibility Antigens
|2 NLM
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|a Isoantigens
|2 NLM
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|a Lipopolysaccharides
|2 NLM
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|a Membrane Proteins
|2 NLM
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| 650 |
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|a Receptors, Antigen, T-Cell
|2 NLM
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| 650 |
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|a flt3 ligand protein
|2 NLM
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| 650 |
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|a Interleukin-4
|2 NLM
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| 650 |
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|a 207137-56-2
|2 NLM
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| 650 |
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|a cytidylyl-3'-5'-guanosine
|2 NLM
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| 650 |
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|a 2382-65-2
|2 NLM
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| 650 |
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|a Granulocyte-Macrophage Colony-Stimulating Factor
|2 NLM
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| 650 |
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|a 83869-56-1
|2 NLM
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| 650 |
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|a Interferons
|2 NLM
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| 650 |
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|a 9008-11-1
|2 NLM
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| 700 |
1 |
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|a Breitinger, Jeremy J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Unadkat, Jignesh V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shufesky, William J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Morelli, Adrian E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Thomson, Angus W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, W P Andrew
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feili-Hariri, Maryam
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 123(2007), 2 vom: 20. Mai, Seite 176-89
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:123
|g year:2007
|g number:2
|g day:20
|g month:05
|g pages:176-89
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| 912 |
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 123
|j 2007
|e 2
|b 20
|c 05
|h 176-89
|