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01000naa a22002652 4500 |
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NLM164290117 |
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DE-627 |
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20231223102157.0 |
| 007 |
tu |
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231223s2006 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed24n0548.xml
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| 035 |
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|a (DE-627)NLM164290117
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| 035 |
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|a (NLM)16857429
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Luan, Hui-Ying
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Monoclonal anti-double-stranded DNA antibodies cross-react with phosphoglycerate kinase 1 and inhibit the expression and production of IL-2 in activated Jurkat T cell line
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| 264 |
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1 |
|c 2006
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 26.09.2006
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| 500 |
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|a Date Revised 21.11.2008
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| 500 |
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|a published: Print-Electronic
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Anti-double strand DNA antibodies (anti-dsDNA) involve in lupus nephritis. However, their role in tissue damage mechanism remains unclear. In this study, a 45-kDa cognate antigen of anti-dsDNA monoclonal antibodies 9D7 was identified by two-dimensional gel electrophoresis and determined to be human phosphoglycerate kinase 1 (PGK-1) by MALDI-TOF analysis. The binding of 9D7 to PGK-1 was not affected by DNase I but was inhibited by thymus dsDNA. Human SLE sera with high anti-dsDNA titers had a high affinity with PGK. In activated Jurkat T cells, 9D7 decreased the PGK-1 mRNA production and IL-2 promoter activity. Reduction in IL-2 gene expression and protein production were observed in the 9D7-treated cells. Because PGK-1 deficiency may cause mental tardy and hemolytic anemia, interaction between anti-dsDNA and PGK-1 may be important in lupus pathogenesis. Moreover, reduction in IL-2 production by anti-dsDNA suggests their role in increasing infection rate and decreasing proper generation of activation-induced cell death
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antibodies, Antinuclear
|2 NLM
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| 650 |
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7 |
|a Antibodies, Monoclonal
|2 NLM
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| 650 |
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7 |
|a Cytokines
|2 NLM
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| 650 |
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7 |
|a Interleukin-2
|2 NLM
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| 650 |
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7 |
|a RNA, Messenger
|2 NLM
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| 650 |
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7 |
|a DNA
|2 NLM
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| 650 |
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7 |
|a 9007-49-2
|2 NLM
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| 650 |
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7 |
|a Phosphoglycerate Kinase
|2 NLM
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| 650 |
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7 |
|a EC 2.7.2.3
|2 NLM
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| 650 |
|
7 |
|a Alkaline Phosphatase
|2 NLM
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| 650 |
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7 |
|a EC 3.1.3.1
|2 NLM
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| 700 |
1 |
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|a Tang, Shye-Jye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Winnie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tsai, Chang-Youh
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Sun, Guang-Huan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Kuang-Hui
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 120(2006), 3 vom: 28. Sept., Seite 326-34
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:120
|g year:2006
|g number:3
|g day:28
|g month:09
|g pages:326-34
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 120
|j 2006
|e 3
|b 28
|c 09
|h 326-34
|