Monoclonal anti-double-stranded DNA antibodies cross-react with phosphoglycerate kinase 1 and inhibit the expression and production of IL-2 in activated Jurkat T cell line

Monoclonal anti-double-stranded DNA antibodies cross-react with phosphoglycerate kinase 1 and inhibit the expression and production of IL-2 in activated Jurkat T cell line

Anti-double strand DNA antibodies (anti-dsDNA) involve in lupus nephritis. However, their role in tissue damage mechanism remains unclear. In this study, a 45-kDa cognate antigen of anti-dsDNA monoclonal antibodies 9D7 was identified by two-dimensional gel electrophoresis and determined to be human...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 120(2006), 3 vom: 28. Sept., Seite 326-34
1. Verfasser: Luan, Hui-Ying (VerfasserIn)
Weitere Verfasser: Tang, Shye-Jye, Yang, Winnie, Tsai, Chang-Youh, Sun, Guang-Huan, Sun, Kuang-Hui
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antibodies, Antinuclear Antibodies, Monoclonal Cytokines Interleukin-2 RNA, Messenger DNA 9007-49-2 Phosphoglycerate Kinase mehr... EC 2.7.2.3 Alkaline Phosphatase EC 3.1.3.1