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01000caa a22002652 4500 |
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NLM161073034 |
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DE-627 |
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tu |
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231223s2006 xx ||||| 00| ||eng c |
| 028 |
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|a pubmed25n0537.xml
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|a (DE-627)NLM161073034
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|a (NLM)16515886
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Manske, Michelle K
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Quantitative analysis of clonal bone marrow CD19+ B cells
|b use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis
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| 264 |
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1 |
|c 2006
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 03.08.2006
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| 500 |
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|a Date Revised 22.03.2007
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| 500 |
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|a published: Print-Electronic
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|a ErratumIn: Clin Immunol. 2007 Mar;122(3):356
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Light chain amyloidosis (AL) is a bone marrow (BM) plasma cell neoplasia with systemic deposition of Ig light chain amyloid fibrils. Here, we report the identification of clonal CD19 B cells in the BM and the use of a novel mathematical algorithm to generate B cell lineage trees of the clonal CD19 B cells and CD138 plasma cells from the BM of AL patients to delineate the relationship between these two clonal populations. The CD19+ clonal B cells in the BM of AL patients related to the clonal plasma cells represent a pre-plasma cell precursor population. The B cell lineage trees from AL patients also show significant differences in clonal diversification and antigenic selection compared to clones from normal, healthy controls. These data provide a robust example of the use of graphical quantification methods in delineating the role of neoplastic precursors in the pathogenesis of hematopoietic malignancies
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antigens, CD19
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin Light Chains
|2 NLM
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| 650 |
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7 |
|a Membrane Glycoproteins
|2 NLM
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| 650 |
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7 |
|a Proteoglycans
|2 NLM
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| 650 |
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7 |
|a SDC1 protein, human
|2 NLM
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| 650 |
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7 |
|a Syndecan-1
|2 NLM
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| 650 |
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7 |
|a Syndecans
|2 NLM
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| 650 |
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|a RNA
|2 NLM
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| 650 |
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|a 63231-63-0
|2 NLM
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| 700 |
1 |
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|a Zuckerman, Neta S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Timm, Michael M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maiden, Stephanie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Edelman, Hanna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shahaf, Gitit
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Barak, Michal
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dispenzieri, Angela
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gertz, Morie A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mehr, Ramit
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Abraham, Roshini S
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 120(2006), 1 vom: 15. Juli, Seite 106-20
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
8 |
|g volume:120
|g year:2006
|g number:1
|g day:15
|g month:07
|g pages:106-20
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 120
|j 2006
|e 1
|b 15
|c 07
|h 106-20
|