Quantitative analysis of clonal bone marrow CD19+ B cells use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis

Quantitative analysis of clonal bone marrow CD19+ B cells : use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis

Light chain amyloidosis (AL) is a bone marrow (BM) plasma cell neoplasia with systemic deposition of Ig light chain amyloid fibrils. Here, we report the identification of clonal CD19 B cells in the BM and the use of a novel mathematical algorithm to generate B cell lineage trees of the clonal CD19 B...

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Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 120(2006), 1 vom: 15. Juli, Seite 106-20
Auteur principal: Manske, Michelle K (Auteur)
Autres auteurs: Zuckerman, Neta S, Timm, Michael M, Maiden, Stephanie, Edelman, Hanna, Shahaf, Gitit, Barak, Michal, Dispenzieri, Angela, Gertz, Morie A, Mehr, Ramit, Abraham, Roshini S
Format: Article
Langue:English
Publié: 2006
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't Antigens, CD19 Immunoglobulin Light Chains Membrane Glycoproteins Proteoglycans SDC1 protein, human Syndecan-1 Syndecans RNA 63231-63-0