Quantitative analysis of clonal bone marrow CD19+ B cells use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis

Quantitative analysis of clonal bone marrow CD19+ B cells : use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis

Light chain amyloidosis (AL) is a bone marrow (BM) plasma cell neoplasia with systemic deposition of Ig light chain amyloid fibrils. Here, we report the identification of clonal CD19 B cells in the BM and the use of a novel mathematical algorithm to generate B cell lineage trees of the clonal CD19 B...

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Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 120(2006), 1 vom: 15. Juli, Seite 106-20
Auteur principal: Manske, Michelle K (Auteur)
Autres auteurs: Zuckerman, Neta S, Timm, Michael M, Maiden, Stephanie, Edelman, Hanna, Shahaf, Gitit, Barak, Michal, Dispenzieri, Angela, Gertz, Morie A, Mehr, Ramit, Abraham, Roshini S
Format: Article
Langue:English
Publié: 2006
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't Antigens, CD19 Immunoglobulin Light Chains Membrane Glycoproteins Proteoglycans SDC1 protein, human Syndecan-1 Syndecans RNA 63231-63-0
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Résumé:Light chain amyloidosis (AL) is a bone marrow (BM) plasma cell neoplasia with systemic deposition of Ig light chain amyloid fibrils. Here, we report the identification of clonal CD19 B cells in the BM and the use of a novel mathematical algorithm to generate B cell lineage trees of the clonal CD19 B cells and CD138 plasma cells from the BM of AL patients to delineate the relationship between these two clonal populations. The CD19+ clonal B cells in the BM of AL patients related to the clonal plasma cells represent a pre-plasma cell precursor population. The B cell lineage trees from AL patients also show significant differences in clonal diversification and antigenic selection compared to clones from normal, healthy controls. These data provide a robust example of the use of graphical quantification methods in delineating the role of neoplastic precursors in the pathogenesis of hematopoietic malignancies
Description:Date Completed 03.08.2006
Date Revised 22.03.2007
published: Print-Electronic
ErratumIn: Clin Immunol. 2007 Mar;122(3):356
Citation Status MEDLINE
ISSN:1521-7035