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01000caa a22002652 4500 |
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NLM126227063 |
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DE-627 |
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20250204043347.0 |
| 007 |
tu |
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231222s2003 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed25n0421.xml
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|a (DE-627)NLM126227063
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| 035 |
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|a (NLM)12865065
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Lamprecht, Peter
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis
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| 264 |
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1 |
|c 2003
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 06.08.2003
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| 500 |
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|a Date Revised 07.11.2019
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4(+)CD28(-) T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4(+)CD28(-) T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4(+)CD28(-) T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4(+)CD28(-) T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4(+)CD28(-)CCR5(+) effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Review
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| 650 |
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7 |
|a CD28 Antigens
|2 NLM
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| 650 |
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7 |
|a Receptors, CCR5
|2 NLM
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| 700 |
1 |
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|a Bruhl, Hilke
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Erdmann, Anika
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Holl-Ulrich, Konstanze
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Csernok, Elena
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Seitzer, Ulrike
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mack, Matthias
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feller, Alfred C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Reinhold-Keller, Eva
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gross, Wolfgang L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Muller, Antje
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 108(2003), 1 vom: 15. Juli, Seite 1-7
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
8 |
|g volume:108
|g year:2003
|g number:1
|g day:15
|g month:07
|g pages:1-7
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 108
|j 2003
|e 1
|b 15
|c 07
|h 1-7
|