Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis

Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4(+)CD28(-) T-cells we studied...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 108(2003), 1 vom: 15. Juli, Seite 1-7
1. Verfasser:	Lamprecht, Peter (VerfasserIn)
Weitere Verfasser:	Bruhl, Hilke, Erdmann, Anika, Holl-Ulrich, Konstanze, Csernok, Elena, Seitzer, Ulrike, Mack, Matthias, Feller, Alfred C, Reinhold-Keller, Eva, Gross, Wolfgang L, Muller, Antje
Format:	Aufsatz
Sprache:	English
Veröffentlicht:	2003
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Review CD28 Antigens Receptors, CCR5

Beschreibung
Zusammenfassung:	Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4(+)CD28(-) T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4(+)CD28(-) T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4(+)CD28(-) T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4(+)CD28(-) T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4(+)CD28(-)CCR5(+) effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation
Beschreibung:	Date Completed 06.08.2003 Date Revised 07.11.2019 published: Print Citation Status MEDLINE
ISSN:	1521-6616