Journal Article Research Support, U.S. Gov't, Non-P.H.S. computer programs serial femtosecond crystallography Macromolecular Substances Research Support, U.S. Gov't, P.H.S. X-ray free-electron laser X-ray free-electron lasers Grid Engine Proteins Research Support, N.I.H., Extramural Review X-ray crystallography XFELS XFELs automated data processing convolutional neural networks data analysis data processing deep learning diffraction data processing indexing and integration macromolecular structure mosaicity multi-crystal data collection strategies partiality postrefinement serial crystallography single-crystal X-ray diffraction