Journal Article neutron protein crystallography Research Support, Non-U.S. Gov't Cellulase EC 3.2.1.- EC 3.2.1.4 Evaluation Study Glycoside Hydrolases Prealbumin Proteins Protons TOF single-crystal diffractometer amyloidosis cellulase crystallization phase diagram high-pressure freezing of large biological macromolecules high-sensitivity detection of hydrogen hydrogen-bond network isotope effect pH sensitivity paramagnetic radical doping proton polarization technique transthyretin