Hydrogen-bond network and pH sensitivity in human transthyretin
Transthyretin (TTR) is a tetrameric protein. TTR misfolding and aggregation are associated with human amyloid diseases. Dissociation of the TTR tetramer is believed to be the rate-limiting step in the amyloid fibril formation cascade. Low pH is known to promote dissociation into monomer and the form...
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| Veröffentlicht in: | Journal of synchrotron radiation. - 1994. - 20(2013), Pt 6 vom: 07. Nov., Seite 834-7
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| 1. Verfasser: |
Yokoyama, Takeshi
(VerfasserIn) |
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| Weitere Verfasser: |
Mizuguchi, Mineyuki,
Nabeshima, Yuko,
Kusaka, Katsuhiro,
Yamada, Taro,
Hosoya, Takaaki,
Ohhara, Takashi,
Kurihara, Kazuo,
Tanaka, Ichiro,
Niimura, Nobuo |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2013
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| Zugriff auf das übergeordnete Werk: | Journal of synchrotron radiation
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| Schlagworte: | Journal Article
amyloidosis
hydrogen-bond network
neutron protein crystallography
pH sensitivity
transthyretin
Prealbumin |
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