Journal Article Research Support, Non-U.S. Gov't 37341-29-0 Adaptor Proteins, Signal Transducing B-Cell Activation Factor Receptor B-cell Case Reports Combined immunodeficiency Common variable immunodeficiency DOCK8 DOCK8 protein, human EC 2.7.10.- Guanine Nucleotide Exchange Factors Hyper-IgE syndrome Immunoglobulin E Immunoglobulin G Immunoglobulin M Intracellular Signaling Peptides and Proteins LRBA protein, human NLRP12 protein, human Phenotypic variability Polygenic RNA, Messenger TNFRSF13B protein, human TNFRSF13C protein, human Transcriptome Transmembrane Activator and CAML Interactor Protein Whole exome sequencing Whole genome sequencing