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241205s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.110413
|2 doi
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|a pubmed24n1622.xml
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|a eng
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| 100 |
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|a Frejo, Lidia
|e verfasserin
|4 aut
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|a Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease
|b A longitudinal study
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Revised 04.12.2024
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
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|a BACKGROUND: Meniere disease (MD), an inner ear disorder influenced by genetic and environmental factors, potentially leads to chronic inflammation. This study evaluates whether inflammation in MD patients is driven by allergy or autoinflammation
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|a METHODS: 2-year longitudinal study. Cytokine and chemokine levels were measured in plasma from 72 patients. Functional clusters were identified using weighted-based discriminant and km3d trajectory analyses. THP-1 cells were exposed to patients' plasma to assess macrophage polarization, and qPCR analyzed upstream cytokine release events
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|a RESULTS: Four groups were identified: 1) Autoimmune (20 %) with high TNF-α (p = 0.0004); 2) Allergic (25 %) with elevated IgE (p < 0.0001) and M2 polarization; 3) Autoinflammatory (13 %) with increased IL-1β (p < 0.0001), activated via CASP1/NLRP3; 4) Low cytokine levels (42 %; cytokines in Q1). Group stability was observed, with 36 % of allergic patients also showing high IL-1β
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|a CONCLUSION: Identified immunophenotypes, allergy-driven IgE responses, and IL-1β-mediated autoinflammation indicate that targeting inflammation with biomarkers could optimize MD treatment and outcomes
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|a Journal Article
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|a Cytokines
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| 650 |
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|a IL-1β
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|a IgE
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| 650 |
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|a Inflammation
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| 650 |
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|a Meniere Disease
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1 |
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|a Cara, Francisca E
|e verfasserin
|4 aut
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|a Flook, Marisa
|e verfasserin
|4 aut
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|a Robles-Bolivar, Paula
|e verfasserin
|4 aut
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|a Escalera-Balsera, Alba
|e verfasserin
|4 aut
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|a Montilla-Ibañez, Maria Alharilla
|e verfasserin
|4 aut
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| 700 |
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|a Dominguez-Duran, Emilio
|e verfasserin
|4 aut
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| 700 |
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|a Martinez-Martinez, Marta
|e verfasserin
|4 aut
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| 700 |
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|a Perez-Carpena, Patricia
|e verfasserin
|4 aut
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| 700 |
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|a Lopez-Escamez, Jose Antonio
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 271(2024) vom: 30. Nov., Seite 110413
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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|g volume:271
|g year:2024
|g day:30
|g month:11
|g pages:110413
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|u http://dx.doi.org/10.1016/j.clim.2024.110413
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