Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease A longitudinal study

Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease : A longitudinal study

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 271(2024) vom: 30. Nov., Seite 110413
1. Verfasser: Frejo, Lidia (VerfasserIn)
Weitere Verfasser: Cara, Francisca E, Flook, Marisa, Robles-Bolivar, Paula, Escalera-Balsera, Alba, Montilla-Ibañez, Maria Alharilla, Dominguez-Duran, Emilio, Martinez-Martinez, Marta, Perez-Carpena, Patricia, Lopez-Escamez, Jose Antonio
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Cytokines IL-1β IgE Inflammation Meniere Disease
Beschreibung
Zusammenfassung:Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
BACKGROUND: Meniere disease (MD), an inner ear disorder influenced by genetic and environmental factors, potentially leads to chronic inflammation. This study evaluates whether inflammation in MD patients is driven by allergy or autoinflammation
METHODS: 2-year longitudinal study. Cytokine and chemokine levels were measured in plasma from 72 patients. Functional clusters were identified using weighted-based discriminant and km3d trajectory analyses. THP-1 cells were exposed to patients' plasma to assess macrophage polarization, and qPCR analyzed upstream cytokine release events
RESULTS: Four groups were identified: 1) Autoimmune (20 %) with high TNF-α (p = 0.0004); 2) Allergic (25 %) with elevated IgE (p < 0.0001) and M2 polarization; 3) Autoinflammatory (13 %) with increased IL-1β (p < 0.0001), activated via CASP1/NLRP3; 4) Low cytokine levels (42 %; cytokines in Q1). Group stability was observed, with 36 % of allergic patients also showing high IL-1β
CONCLUSION: Identified immunophenotypes, allergy-driven IgE responses, and IL-1β-mediated autoinflammation indicate that targeting inflammation with biomarkers could optimize MD treatment and outcomes
Beschreibung:Date Revised 04.12.2024
published: Print-Electronic
Citation Status Publisher
ISSN:1521-7035
DOI:10.1016/j.clim.2024.110413