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241012s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.110378
|2 doi
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|a pubmed24n1590.xml
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|a eng
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|a Boudigou, Marina
|e verfasserin
|4 aut
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|a Phenotypic, transcriptomic, and spatial characterization of CD45RB+ naïve mature B cells
|b Implications in Sjögren's disease
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 04.11.2024
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|a Date Revised 04.11.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024. Published by Elsevier Inc.
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|a The conventional classification of mature B cells overlooks the diversity within IgD+ CD27- naïve B cells. Here, to identify distinct mature naïve B cells, we categorized CD45RBMEM55- B cells (NA RB-) and CD45RBMEM55+ B cells (NA RB+) and explore their function and localization in circulation and tissues under physiological and pathological conditions. NA RB+ B cells, found in secondary lymphoid organs, differentiate into plasmablasts and secrete IgM. In Sjögren's disease, their numbers decrease, and they show over-activation and abnormal migration, suggesting an adaptive disease response. NA RB+ B cells also appear in inflamed salivary glands, indicating involvement in local immune responses. These findings highlight the distinct roles of NA RB+ B cells in health and Sjögren's disease
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|a Journal Article
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|a CD45RB(+)CD45RA(high) IgD(+)CD27(−) human B cells
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|a High parameter imaging mass cytometry
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| 650 |
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|a Inflamed tissues
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|a Sjögren's disease
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| 650 |
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|a Leukocyte Common Antigens
|2 NLM
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| 650 |
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|a EC 3.1.3.48
|2 NLM
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| 650 |
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|a Immunoglobulin M
|2 NLM
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| 700 |
1 |
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|a Frutoso, Marie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hémon, Patrice
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Le Dantec, Christelle
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chatzis, Loukas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Devauchelle, Valérie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jamin, Christophe
|e verfasserin
|4 aut
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| 700 |
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|a Cornec, Divi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pers, Jacques-Olivier
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Le Pottier, Laëtitia
|e verfasserin
|4 aut
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| 700 |
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|a Hillion, Sophie
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 268(2024) vom: 10. Nov., Seite 110378
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:268
|g year:2024
|g day:10
|g month:11
|g pages:110378
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|u http://dx.doi.org/10.1016/j.clim.2024.110378
|3 Volltext
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