Phenotypic, transcriptomic, and spatial characterization of CD45RB+ naïve mature B cells Implications in Sjögren's disease

Phenotypic, transcriptomic, and spatial characterization of CD45RB+ naïve mature B cells : Implications in Sjögren's disease

Copyright © 2024. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 268(2024) vom: 10. Okt., Seite 110378
1. Verfasser: Boudigou, Marina (VerfasserIn)
Weitere Verfasser: Frutoso, Marie, Hémon, Patrice, Le Dantec, Christelle, Chatzis, Loukas, Devauchelle, Valérie, Jamin, Christophe, Cornec, Divi, Pers, Jacques-Olivier, Le Pottier, Laëtitia, Hillion, Sophie
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article CD45RB(+)CD45RA(high) IgD(+)CD27(−) human B cells High parameter imaging mass cytometry Inflamed tissues Sjögren's disease
Beschreibung
Zusammenfassung:Copyright © 2024. Published by Elsevier Inc.
The conventional classification of mature B cells overlooks the diversity within IgD+ CD27- naïve B cells. Here, to identify distinct mature naïve B cells, we categorized CD45RBMEM55- B cells (NA RB-) and CD45RBMEM55+ B cells (NA RB+) and explore their function and localization in circulation and tissues under physiological and pathological conditions. NA RB+ B cells, found in secondary lymphoid organs, differentiate into plasmablasts and secrete IgM. In Sjögren's disease, their numbers decrease, and they show over-activation and abnormal migration, suggesting an adaptive disease response. NA RB+ B cells also appear in inflamed salivary glands, indicating involvement in local immune responses. These findings highlight the distinct roles of NA RB+ B cells in health and Sjögren's disease
Beschreibung:Date Revised 19.10.2024
published: Print-Electronic
Citation Status Publisher
ISSN:1521-7035
DOI:10.1016/j.clim.2024.110378