Phenotypic, transcriptomic, and spatial characterization of CD45RB+ naïve mature B cells : Implications in Sjögren's disease

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 268(2024) vom: 10. Nov., Seite 110378
1. Verfasser:	Boudigou, Marina (VerfasserIn)
Weitere Verfasser:	Frutoso, Marie, Hémon, Patrice, Le Dantec, Christelle, Chatzis, Loukas, Devauchelle, Valérie, Jamin, Christophe, Cornec, Divi, Pers, Jacques-Olivier, Le Pottier, Laëtitia, Hillion, Sophie
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2024
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article CD45RB(+)CD45RA(high) IgD(+)CD27(−) human B cells High parameter imaging mass cytometry Inflamed tissues Sjögren's disease Leukocyte Common Antigens EC 3.1.3.48 Immunoglobulin M

Beschreibung
Zusammenfassung:	Copyright © 2024. Published by Elsevier Inc. The conventional classification of mature B cells overlooks the diversity within IgD+ CD27- naïve B cells. Here, to identify distinct mature naïve B cells, we categorized CD45RBMEM55- B cells (NA RB-) and CD45RBMEM55+ B cells (NA RB+) and explore their function and localization in circulation and tissues under physiological and pathological conditions. NA RB+ B cells, found in secondary lymphoid organs, differentiate into plasmablasts and secrete IgM. In Sjögren's disease, their numbers decrease, and they show over-activation and abnormal migration, suggesting an adaptive disease response. NA RB+ B cells also appear in inflamed salivary glands, indicating involvement in local immune responses. These findings highlight the distinct roles of NA RB+ B cells in health and Sjögren's disease
Beschreibung:	Date Completed 04.11.2024 Date Revised 04.11.2024 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2024.110378