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|a 10.1002/adma.202404606
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|a pubmed24n1587.xml
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|a eng
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|a Rajesh, Netra U
|e verfasserin
|4 aut
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|a 3D-Printed Latticed Microneedle Array Patches for Tunable and Versatile Intradermal Delivery
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 01.11.2024
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|a Date Revised 01.11.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.
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|a Using high-resolution 3D printing, a novel class of microneedle array patches (MAPs) is introduced, called latticed MAPs (L-MAPs). Unlike most MAPs which are composed of either solid structures or hollow needles, L-MAPs incorporate tapered struts that form hollow cells capable of trapping liquid droplets. The lattice structures can also be coated with traditional viscous coating formulations, enabling both liquid- and solid-state cargo delivery, on a single patch. Here, a library of 43 L-MAP designs is generated and in-silico modeling is used to down-select optimal geometries for further characterization. Compared to traditionally molded and solid-coated MAPs, L-MAPs can load more cargo with fewer needles per patch, enhancing cargo loading and drug delivery capabilities. Further, L-MAP cargo release kinetics into the skin can be tuned based on formulation and needle geometry. In this work, the utility of L-MAPs as a platform is demonstrated for the delivery of small molecules, mRNA lipid nanoparticles, and solid-state ovalbumin protein. In addition, the production of programmable L-MAPs is demonstrated with tunable cargo release profiles, enabled by combining needle geometries on a single patch
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|a Journal Article
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|a 3D printing
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|a intradermal drug delivery
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|a lattices
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|a microneedles
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|a nucleic acids
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|a proteins
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|a small molecules
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|a Ovalbumin
|2 NLM
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|a 9006-59-1
|2 NLM
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|a Luna Hwang, Jihyun
|e verfasserin
|4 aut
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|a Xu, Yue
|e verfasserin
|4 aut
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|a Saccone, Max A
|e verfasserin
|4 aut
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|a Hung, Andy H
|e verfasserin
|4 aut
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|a Hernandez, Rosa A S
|e verfasserin
|4 aut
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|a Coates, Ian A
|e verfasserin
|4 aut
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|a Driskill, Madison M
|e verfasserin
|4 aut
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|a Dulay, Maria T
|e verfasserin
|4 aut
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|a Jacobson, Gunilla B
|e verfasserin
|4 aut
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|a Tian, Shaomin
|e verfasserin
|4 aut
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|a Perry, Jillian L
|e verfasserin
|4 aut
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|a DeSimone, Joseph M
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 44 vom: 16. Nov., Seite e2404606
|w (DE-627)NLM098206397
|x 1521-4095
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|g volume:36
|g year:2024
|g number:44
|g day:16
|g month:11
|g pages:e2404606
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|u http://dx.doi.org/10.1002/adma.202404606
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