3D-Printed Latticed Microneedle Array Patches for Tunable and Versatile Intradermal Delivery

3D-Printed Latticed Microneedle Array Patches for Tunable and Versatile Intradermal Delivery

© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 44 vom: 16. Nov., Seite e2404606
1. Verfasser: Rajesh, Netra U (VerfasserIn)
Weitere Verfasser: Luna Hwang, Jihyun, Xu, Yue, Saccone, Max A, Hung, Andy H, Hernandez, Rosa A S, Coates, Ian A, Driskill, Madison M, Dulay, Maria T, Jacobson, Gunilla B, Tian, Shaomin, Perry, Jillian L, DeSimone, Joseph M
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article 3D printing intradermal drug delivery lattices microneedles nucleic acids proteins small molecules Ovalbumin 9006-59-1
Beschreibung
Zusammenfassung:© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.
Using high-resolution 3D printing, a novel class of microneedle array patches (MAPs) is introduced, called latticed MAPs (L-MAPs). Unlike most MAPs which are composed of either solid structures or hollow needles, L-MAPs incorporate tapered struts that form hollow cells capable of trapping liquid droplets. The lattice structures can also be coated with traditional viscous coating formulations, enabling both liquid- and solid-state cargo delivery, on a single patch. Here, a library of 43 L-MAP designs is generated and in-silico modeling is used to down-select optimal geometries for further characterization. Compared to traditionally molded and solid-coated MAPs, L-MAPs can load more cargo with fewer needles per patch, enhancing cargo loading and drug delivery capabilities. Further, L-MAP cargo release kinetics into the skin can be tuned based on formulation and needle geometry. In this work, the utility of L-MAPs as a platform is demonstrated for the delivery of small molecules, mRNA lipid nanoparticles, and solid-state ovalbumin protein. In addition, the production of programmable L-MAPs is demonstrated with tunable cargo release profiles, enabled by combining needle geometries on a single patch
Beschreibung:Date Completed 01.11.2024
Date Revised 01.11.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202404606