Direct Chiral Discrimination with NMR
© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.
| Veröffentlicht in: | Advanced materials (Deerfield Beach, Fla.). - 1998. - (2024) vom: 23. Aug., Seite e2408547 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2024
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| Zugriff auf das übergeordnete Werk: | Advanced materials (Deerfield Beach, Fla.) |
| Schlagworte: | Journal Article NMR chirality drug discovery enantiomeric excess |
| Zusammenfassung: | © 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH. Unaided nuclear magnetic resonance (NMR) spectroscopy is considered incapable of distinguishing enantiomers. However, as first derived by A.D. Buckingham, the tensor coupling the electric and magnetic dipoles is space-dependent, which varies according to the molecular structure, hence, would be different for two enantiomers. Exploiting the odd-parity coupling tensor, a new variant of a double-resonant radiofrequency (RF) NMR detector is developed, which is sensitive to both electric and magnetic dipoles. Using the detector, a new method for liquid-state NMR is developed and elaborated, with which two enantiomers are successfully discriminated |
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| Beschreibung: | Date Revised 24.08.2024 published: Print-Electronic Citation Status Publisher |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.202408547 |