Monolithic DNApatite : An Elastic Apatite with Sub-Nanometer Scale Organo-Inorganic Structures

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 41 vom: 07. Okt., Seite e2406179
1. Verfasser:	Lee, Jin Woong (VerfasserIn)
Weitere Verfasser:	Lee, Byoungsang, Park, Cheol Hyun, Heo, Jun Hyuk, Lee, Tae Yoon, Lee, Dongtak, Bae, Jina, Sundharbaabu, Priyannth Ramasami, Yeom, Won Kyun, Chae, Sudong, Lim, Jae-Hyuk, Lee, Seok-Won, Choi, Jin-Seok, Bae, Hyung-Bin, Choi, Jae-Young, Lee, Eun-Ho, Yoon, Dae Sung, Yeom, Geun Young, Shin, Hyunjung, Lee, Jung Heon
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2024
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article DNA DNApatite bone mimicking structure elastic apatite organo–inorganic structure sub‐nanometer nacre mimetic architecture

Beschreibung
Zusammenfassung:	© 2024 Wiley‐VCH GmbH. Hydroxyapatite (HA) exhibits outstanding biocompatibility, bioactivity, osteoconductivity, and natural anti-inflammatory properties. Pure HA, ion-doped HA, and HA-polymer composites are investigated, but critical limitations such as brittleness remain; numerous efforts are being made to address them. Herein, the novel self-crystallization of a polymeric single-stranded deoxyribonucleic acid (ssDNA) without additional phosphate ions for synthesizing deoxyribonucleic apatite (DNApatite) is presented. The synthesized DNApatite, DNA1Ca2.2(PO4)1.3OH2.1, has a repetitive dual phase of inorganic HA crystals and amorphous organic ssDNA at the sub-nm scale, forming nanorods. Its mechanical properties, including toughness and elasticity, are significantly enhanced compared with those of HA nanorod, with a Young's modulus similar to that of natural bone
Beschreibung:	Date Revised 10.10.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202406179