Water Transport-Induced Liquid-Liquid Phase Separation Facilitates Gelation for Controllable and Facile Fabrication of Physically Crosslinked Microgels

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 35 vom: 18. Aug., Seite e2405109
1. Verfasser:	Chen, Michael W (VerfasserIn)
Weitere Verfasser:	Fan, Dongdong, Liu, Xiangjian, Han, Dongbo, Jin, Yuhong, Ao, Yanxiao, Chen, Yuyang, Liu, Zhiqiang, Feng, Yiting, Ling, Sida, Liang, Kaini, Kong, Wenyu, Xu, Jianhong, Du, Yanan
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2024
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article liquid–liquid phase separation microgels physical crosslink water transport Water 059QF0KO0R Microgels Emulsions Biocompatible Materials Cross-Linking Reagents

Beschreibung
Zusammenfassung:	© 2024 Wiley‐VCH GmbH. Physically crosslinked microgels (PCMs) offer a biocompatible platform for various biomedical applications. However, current PCM fabrication methods suffer from their complexity and poor controllability, due to their reliance on altering physical conditions to initiate gelation and their dependence on specific materials. To address this issue, a novel PCM fabrication method is devised, which employs water transport-induced liquid-liquid phase separation (LLPS) to trigger the intermolecular interaction-supported sol-gel transition within aqueous emulsion droplets. This method enables the controllable and facile generation of PCMs through a single emulsification step, allowing for the facile production of PCMs with various materials and sizes, as well as controllable structures and mechanical properties. Moreover, this PCM fabrication method holds great promise for diverse biomedical applications. The interior of the PCM not only supports the encapsulation and proliferation of bacteria but also facilitates the encapsulation of eukaryotic cells after transforming the system into an all-aqueous emulsion. Furthermore, through appropriate surface functionalization, the PCMs effectively activate T cells in vitro upon coculturing. This work represents an advancement in PCM fabrication and offers new insights and perspectives for microgel engineering
Beschreibung:	Date Completed 28.08.2024 Date Revised 28.08.2024 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202405109