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240523s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202405547
|2 doi
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|a pubmed24n1488.xml
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|a eng
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|a Hu, Jiangnan
|e verfasserin
|4 aut
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|a Intranasal Delivery of Near-Infrared and Magnetic Dual-Response Nanospheres to Rapidly Produce Antidepressant-Like and Cognitive Enhancement Effects
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 01.08.2024
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|a Date Revised 01.08.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.
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|a Restricted by synaptic plasticity, dopamine receptor (DR) upregulation takes a long time to work. Moreover, the impact of the blood-brain barrier (BBB) on delivery efficiency restricts the development of drugs. Taking inspiration from snuff bottles, a convenient, fast-acting, and nonaddictive nasal drug delivery system has been developed to rapidly reshape the balance of synaptic transmitters. This optical and magnetic response system called CFsDP, comprised of carbonized MIL-100 (Fe) frameworks (CFs) and domperidone (DP), which can enter the brain via nasal administration. Under dual stimulation of near-infrared (NIR) irradiation and catecholamine-induced complexation, CFs@DP disintegrates to release iron ions and DP, causing upregulation of the dopamine type 1 (D1), type 2 (D2) receptors, and brain-derived neurotrophic factor (BDNF) to achieve a therapeutic effect. In vivo experiments demonstrate that the DR density of mice (postnatal day 50-60) increased in the prefrontal cortex (PFC) and the hippocampus (HPC) after 10 days of therapy, resulting in antidepressant-like and cognitive enhancement effects. Interestingly, the cognitive enhancement effect of CFs@DP is even working in noniron deficiency (normal fed) mice, making it a promising candidate for application in enhancing learning ability
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|a Journal Article
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|a dopamine receptor
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|a iron
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|a nasal administration
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|a receptor upregulation
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|a synaptic plasticity
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|a Antidepressive Agents
|2 NLM
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| 650 |
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|a Brain-Derived Neurotrophic Factor
|2 NLM
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| 700 |
1 |
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|a Lian, Zhenglong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Weng, Zhenzhen
|e verfasserin
|4 aut
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| 700 |
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|a Xu, Zihao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Jie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Yuanyuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Xiaolei
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 31 vom: 31. Aug., Seite e2405547
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|g volume:36
|g year:2024
|g number:31
|g day:31
|g month:08
|g pages:e2405547
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|u http://dx.doi.org/10.1002/adma.202405547
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