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240315s2024 xx |||||o 00| ||eng c |
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|a 10.1111/nph.19683
|2 doi
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|a pubmed24n1373.xml
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|a (NLM)38481385
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Ren, Zhiyong
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Sirt5-mediated lysine desuccinylation regulates oxidative stress adaptation in Magnaporthe oryzae during host intracellular infection
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 12.04.2024
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|a Date Revised 12.04.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 The Authors. New Phytologist © 2024 New Phytologist Foundation.
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|a Plant pathogenic fungi elaborate numerous detoxification strategies to suppress host reactive oxygen species (ROS), but their coordination is not well-understood. Here, we show that Sirt5-mediated protein desuccinylation in Magnaporthe oryzae is central to host ROS detoxification. SIRT5 encodes a desuccinylase important for virulence via adaptation to host oxidative stress. Quantitative proteomics analysis identified a large number of succinylated proteins targeted by Sirt5, most of which were mitochondrial proteins involved in oxidative phosphorylation, TCA cycle, and fatty acid oxidation. Deletion of SIRT5 resulted in hypersuccinylation of detoxification-related enzymes, and significant reduction in NADPH : NADP+ and GSH : GSSG ratios, disrupting redox balance and impeding invasive growth. Sirt5 desuccinylated thioredoxin Trx2 and glutathione peroxidase Hyr1 to activate their enzyme activity, likely by affecting proper folding. Altogether, this work demonstrates the importance of Sirt5-mediated desuccinylation in controlling fungal process required for detoxifying host ROS during M. oryzae infection
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|a Journal Article
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|a Magnaporthe oryzae
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| 650 |
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|a ROS detoxification
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| 650 |
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|a Sirt5
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|a desuccinylation
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| 650 |
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4 |
|a oxidative stress
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| 650 |
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|a Reactive Oxygen Species
|2 NLM
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| 650 |
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|a Lysine
|2 NLM
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| 650 |
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|a K3Z4F929H6
|2 NLM
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| 650 |
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|a Fungal Proteins
|2 NLM
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| 700 |
1 |
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|a Dong, Xiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guan, Lun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Caiyun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cai, Xuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lv, Ziwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Hao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Lu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Junbin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wilson, Richard A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xiao-Lin
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 242(2024), 3 vom: 13. Apr., Seite 1257-1274
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:242
|g year:2024
|g number:3
|g day:13
|g month:04
|g pages:1257-1274
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| 856 |
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|u http://dx.doi.org/10.1111/nph.19683
|3 Volltext
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