Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy
© 2024 The Authors. Advanced Materials published by Wiley‐VCH GmbH.
| Publié dans: | Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 28 vom: 01. Juli, Seite e2307106 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , , , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2024
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| Accès à la collection: | Advanced materials (Deerfield Beach, Fla.) |
| Sujets: | Journal Article cavitation gas vesicles molecular imaging nanomedicine ultrasound Contrast Media |
| Résumé: | © 2024 The Authors. Advanced Materials published by Wiley‐VCH GmbH. Nanotechnology offers significant advantages for medical imaging and therapy, including enhanced contrast and precision targeting. However, integrating these benefits into ultrasonography is challenging due to the size and stability constraints of conventional bubble-based agents. Here bicones, truly tiny acoustic contrast agents based on gas vesicles (GVs), a unique class of air-filled protein nanostructures naturally produced in buoyant microbes, are described. It is shown that these sub-80 nm particles can be effectively detected both in vitro and in vivo, infiltrate tumors via leaky vasculature, deliver potent mechanical effects through ultrasound-induced inertial cavitation, and are easily engineered for molecular targeting, prolonged circulation time, and payload conjugation |
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| Description: | Date Completed 12.07.2024 Date Revised 04.01.2025 published: Print-Electronic UpdateOf: bioRxiv. 2023 Jun 28:2023.06.27.546773. doi: 10.1101/2023.06.27.546773. - PMID 37425749 Citation Status MEDLINE |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.202307106 |