Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy

Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy

© 2024 The Authors. Advanced Materials published by Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 28 vom: 01. Juli, Seite e2307106
1. Verfasser: Ling, Bill (VerfasserIn)
Weitere Verfasser: Gungoren, Bilge, Yao, Yuxing, Dutka, Przemysław, Vassallo, Reid, Nayak, Rohit, Smith, Cameron A B, Lee, Justin, Swift, Margaret B, Shapiro, Mikhail G
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article cavitation gas vesicles molecular imaging nanomedicine ultrasound Contrast Media
Beschreibung
Zusammenfassung:© 2024 The Authors. Advanced Materials published by Wiley‐VCH GmbH.
Nanotechnology offers significant advantages for medical imaging and therapy, including enhanced contrast and precision targeting. However, integrating these benefits into ultrasonography is challenging due to the size and stability constraints of conventional bubble-based agents. Here bicones, truly tiny acoustic contrast agents based on gas vesicles (GVs), a unique class of air-filled protein nanostructures naturally produced in buoyant microbes, are described. It is shown that these sub-80 nm particles can be effectively detected both in vitro and in vivo, infiltrate tumors via leaky vasculature, deliver potent mechanical effects through ultrasound-induced inertial cavitation, and are easily engineered for molecular targeting, prolonged circulation time, and payload conjugation
Beschreibung:Date Completed 12.07.2024
Date Revised 04.01.2025
published: Print-Electronic
UpdateOf: bioRxiv. 2023 Jun 28:2023.06.27.546773. doi: 10.1101/2023.06.27.546773. - PMID 37425749
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202307106