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240210s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202311733
|2 doi
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|a pubmed24n1417.xml
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|a (DE-627)NLM368294080
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|a (NLM)38339920
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|a DE-627
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|a eng
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| 100 |
1 |
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|a Wang, He
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Transformable Supramolecular Self-Assembled Peptides for Cascade Self-Enhanced Ferroptosis Primed Cancer Immunotherapy
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 24.05.2024
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|a Date Revised 24.05.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Immunotherapy has received widespread attention for its effective and long-term tumor-eliminating ability. However, for immunogenic "cold" tumors, such as prostate cancer (PCa), the low immunogenicity of the tumor itself is a serious obstacle to efficacy. Here, this work reports a strategy to enhance PCa immunogenicity by triggering cascade self-enhanced ferroptosis in tumor cells, turning the tumor from "cold" to "hot". This work develops a transformable self-assembled peptide TEP-FFG-CRApY with alkaline phosphatase (ALP) responsiveness and glutathione peroxidase 4 (GPX4) protein targeting. TEP-FFG-CRApY self-assembles into nanoparticles under aqueous conditions and transforms into nanofibers in response to ALP during endosome/lysosome uptake into tumor cells, promoting lysosomal membrane permeabilization (LMP). On the one hand, the released TEP-FFG-CRAY nanofibers target GPX4 and selectively degrade the GPX4 protein under the light irradiation, inducing ferroptosis; on the other hand, the large amount of leaked Fe2+ further cascade to amplify the ferroptosis through the Fenton reaction. TEP-FFG-CRApY-induced immunogenic ferroptosis improves tumor cell immunogenicity by promoting the maturation of dendritic cells (DCs) and increasing intratumor T-cell infiltration. More importantly, recovered T cells further enhance ferroptosis by secreting large amounts of interferon-gamma (IFN-γ). This work provides a novel strategy for the molecular design of synergistic molecularly targeted therapy for immunogenic "cold" tumors
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4 |
|a Journal Article
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|a enzyme‐instructed peptide self‐assembly (EISA)
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|a ferroptosis
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4 |
|a immunogenic cell death
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| 650 |
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|a lysosomal‐membrane permeabilization
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| 650 |
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4 |
|a prostate cancer
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| 650 |
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7 |
|a Peptides
|2 NLM
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| 650 |
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|a Phospholipid Hydroperoxide Glutathione Peroxidase
|2 NLM
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| 650 |
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7 |
|a EC 1.11.1.12
|2 NLM
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| 700 |
1 |
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|a Jiao, Di
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feng, Dexiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Qian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Yuhua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hou, Jianquan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ding, Dan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Weijie
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 21 vom: 24. Mai, Seite e2311733
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:36
|g year:2024
|g number:21
|g day:24
|g month:05
|g pages:e2311733
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|u http://dx.doi.org/10.1002/adma.202311733
|3 Volltext
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