An Antioxidative and Active Shrinkage Hydrogel Integratedly Promotes Re-Epithelization and Skin Constriction for Enhancing Wound Closure

An Antioxidative and Active Shrinkage Hydrogel Integratedly Promotes Re-Epithelization and Skin Constriction for Enhancing Wound Closure

© 2024 The Authors. Advanced Materials published by Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 21 vom: 24. Mai, Seite e2312440
1. Verfasser: Sun, Jiacheng (VerfasserIn)
Weitere Verfasser: Jia, Wang, Qi, Hedong, Huo, Jiawei, Liao, Xiaodan, Xu, Yuan, Wang, Jun, Sun, Zihao, Liu, Yang, Liu, Jingchao, Zhen, Mingming, Wang, Chunru, Bai, Chunli
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article acute and diabetic chronic wound healing fullerene hydrogel re‐epithelization skin constriction Hydrogels Antioxidants Fullerenes Reactive Oxygen Species mehr... ErbB Receptors EC 2.7.10.1 Proto-Oncogene Proteins c-akt EC 2.7.11.1
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520 |a Delayed re-epithelization and weakened skin contractions are the two primary factors that hinder wound closure in large-scale acute or chronic wounds. However, effective strategies for targeting these two aspects concurrently are still lacking. Herein, an antioxidative active-shrinkage hydrogel (AHFAS Gel) is constructed that can integratedly promote re-epithelization and skin constriction to accelerate large-scale acute and diabetic chronic wound closure. The AHF@AS Gel is encapsulated by antioxidative amino- and hydroxyl-modified C70 fullerene (AHF) and a thermosensitive active shrinkage hydrogel (AS Gel). Specifically, AHF relieves overactivated inflammation, prevents cellular apoptosis, and promotes fibroblast migration in vitro by reducing excessive reactive oxygen species (ROS). Notably, the AHF@AS Gel achieved ≈2.7-fold and ≈1.7-fold better re-epithelization in acute wounds and chronic diabetic wounds, respectively, significantly contributing to the promotion of wound closure. Using proteomic profiling and mechanistic studies, it is identified that the AHF@AS Gel efficiently promoted the transition of the inflammatory and proliferative phases to the remodeling phase. Notably, it is demonstrated that AS Gel alone activates the mechanosensitive epidermal growth factor receptor/Akt (EGFR/Akt) pathway and promotes cell proliferation. The antioxidative active shrinkage hydrogel offers a comprehensive strategy for acute wound and diabetic chronic wound closure via biochemistry regulation integrating with mechanical forces stimulation 
650 4 |a Journal Article 
650 4 |a acute and diabetic chronic wound healing 
650 4 |a fullerene 
650 4 |a hydrogel 
650 4 |a re‐epithelization 
650 4 |a skin constriction 
650 7 |a Hydrogels  |2 NLM 
650 7 |a Antioxidants  |2 NLM 
650 7 |a Fullerenes  |2 NLM 
650 7 |a Reactive Oxygen Species  |2 NLM 
650 7 |a ErbB Receptors  |2 NLM 
650 7 |a EC 2.7.10.1  |2 NLM 
650 7 |a Proto-Oncogene Proteins c-akt  |2 NLM 
650 7 |a EC 2.7.11.1  |2 NLM 
700 1 |a Jia, Wang  |e verfasserin  |4 aut 
700 1 |a Qi, Hedong  |e verfasserin  |4 aut 
700 1 |a Huo, Jiawei  |e verfasserin  |4 aut 
700 1 |a Liao, Xiaodan  |e verfasserin  |4 aut 
700 1 |a Xu, Yuan  |e verfasserin  |4 aut 
700 1 |a Wang, Jun  |e verfasserin  |4 aut 
700 1 |a Sun, Zihao  |e verfasserin  |4 aut 
700 1 |a Liu, Yang  |e verfasserin  |4 aut 
700 1 |a Liu, Jingchao  |e verfasserin  |4 aut 
700 1 |a Zhen, Mingming  |e verfasserin  |4 aut 
700 1 |a Wang, Chunru  |e verfasserin  |4 aut 
700 1 |a Bai, Chunli  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 36(2024), 21 vom: 24. Mai, Seite e2312440  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:36  |g year:2024  |g number:21  |g day:24  |g month:05  |g pages:e2312440 
856 4 0 |u http://dx.doi.org/10.1002/adma.202312440  |3 Volltext 
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