An Antioxidative and Active Shrinkage Hydrogel Integratedly Promotes Re-Epithelization and Skin Constriction for Enhancing Wound Closure

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 21 vom: 24. Mai, Seite e2312440
1. Verfasser:	Sun, Jiacheng (VerfasserIn)
Weitere Verfasser:	Jia, Wang, Qi, Hedong, Huo, Jiawei, Liao, Xiaodan, Xu, Yuan, Wang, Jun, Sun, Zihao, Liu, Yang, Liu, Jingchao, Zhen, Mingming, Wang, Chunru, Bai, Chunli
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2024
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article acute and diabetic chronic wound healing fullerene hydrogel re‐epithelization skin constriction Hydrogels Antioxidants Fullerenes Reactive Oxygen Species mehr... ErbB Receptors EC 2.7.10.1 Proto-Oncogene Proteins c-akt EC 2.7.11.1

Beschreibung
Zusammenfassung:	© 2024 The Authors. Advanced Materials published by Wiley‐VCH GmbH. Delayed re-epithelization and weakened skin contractions are the two primary factors that hinder wound closure in large-scale acute or chronic wounds. However, effective strategies for targeting these two aspects concurrently are still lacking. Herein, an antioxidative active-shrinkage hydrogel (AHFAS Gel) is constructed that can integratedly promote re-epithelization and skin constriction to accelerate large-scale acute and diabetic chronic wound closure. The AHF@AS Gel is encapsulated by antioxidative amino- and hydroxyl-modified C70 fullerene (AHF) and a thermosensitive active shrinkage hydrogel (AS Gel). Specifically, AHF relieves overactivated inflammation, prevents cellular apoptosis, and promotes fibroblast migration in vitro by reducing excessive reactive oxygen species (ROS). Notably, the AHF@AS Gel achieved ≈2.7-fold and ≈1.7-fold better re-epithelization in acute wounds and chronic diabetic wounds, respectively, significantly contributing to the promotion of wound closure. Using proteomic profiling and mechanistic studies, it is identified that the AHF@AS Gel efficiently promoted the transition of the inflammatory and proliferative phases to the remodeling phase. Notably, it is demonstrated that AS Gel alone activates the mechanosensitive epidermal growth factor receptor/Akt (EGFR/Akt) pathway and promotes cell proliferation. The antioxidative active shrinkage hydrogel offers a comprehensive strategy for acute wound and diabetic chronic wound closure via biochemistry regulation integrating with mechanical forces stimulation
Beschreibung:	Date Completed 24.05.2024 Date Revised 24.05.2024 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202312440