IL-10-producing regulatory cells impact on celiac disease evolution

IL-10-producing regulatory cells impact on celiac disease evolution

Copyright © 2023. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 260(2024) vom: 11. März, Seite 109923
1. Verfasser: Passerini, Laura (VerfasserIn)
Weitere Verfasser: Amodio, Giada, Bassi, Virginia, Vitale, Serena, Mottola, Ilaria, Di Stefano, Marina, Fanti, Lorella, Sgaramella, Paola, Ziparo, Chiara, Furio, Silvia, Auricchio, Renata, Barera, Graziano, Di Nardo, Giovanni, Troncone, Riccardo, Gianfrani, Carmen, Gregori, Silvia
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Gliadin-specific T cells Interleukin 10 Potential celiac disease T regulatory type 1 Tolerogenic dendritic cells Villous atrophy Gliadin 9007-90-3 mehr... Interleukin-10 130068-27-8 Glutens 8002-80-0 Cytokines
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520 |a Celiac Disease (CD) is a T-cell mediated disorder caused by immune response to gluten, although the mechanisms underlying CD progression are still elusive. We analyzed immune cell composition, plasma cytokines, and gliadin-specific T-cell responses in patients with positive serology and normal intestinal mucosa (potential-CD) or villous atrophy (acute-CD), and after gluten-free diet (GFD). We found: an inflammatory signature and the presence of circulating gliadin-specific IFN-γ+ T cells in CD patients regardless of mucosal damage; an increased frequency of IL-10-secreting dendritic cells (DC-10) in the gut and of circulating gliadin-specific IL-10-secreting T cells in potential-CD; IL-10 inhibition increased IFN-γ secretion by gliadin-specific intestinal T cells from acute- and potential-CD. On GFD, inflammatory cytokines normalized, while IL-10-producing T cells accumulated in the gut. We show that IL-10-producing cells are fundamental in controlling pathological T-cell responses to gluten: DC-10 protect the intestinal mucosa from damage and represent a marker of potential-CD 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Gliadin-specific T cells 
650 4 |a Interleukin 10 
650 4 |a Potential celiac disease 
650 4 |a T regulatory type 1 
650 4 |a Tolerogenic dendritic cells 
650 4 |a Villous atrophy 
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700 1 |a Amodio, Giada  |e verfasserin  |4 aut 
700 1 |a Bassi, Virginia  |e verfasserin  |4 aut 
700 1 |a Vitale, Serena  |e verfasserin  |4 aut 
700 1 |a Mottola, Ilaria  |e verfasserin  |4 aut 
700 1 |a Di Stefano, Marina  |e verfasserin  |4 aut 
700 1 |a Fanti, Lorella  |e verfasserin  |4 aut 
700 1 |a Sgaramella, Paola  |e verfasserin  |4 aut 
700 1 |a Ziparo, Chiara  |e verfasserin  |4 aut 
700 1 |a Furio, Silvia  |e verfasserin  |4 aut 
700 1 |a Auricchio, Renata  |e verfasserin  |4 aut 
700 1 |a Barera, Graziano  |e verfasserin  |4 aut 
700 1 |a Di Nardo, Giovanni  |e verfasserin  |4 aut 
700 1 |a Troncone, Riccardo  |e verfasserin  |4 aut 
700 1 |a Gianfrani, Carmen  |e verfasserin  |4 aut 
700 1 |a Gregori, Silvia  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 260(2024) vom: 11. März, Seite 109923  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:260  |g year:2024  |g day:11  |g month:03  |g pages:109923 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2024.109923  |3 Volltext 
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