IL-10-producing regulatory cells impact on celiac disease evolution

IL-10-producing regulatory cells impact on celiac disease evolution

Copyright © 2023. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 260(2024) vom: 11. März, Seite 109923
1. Verfasser: Passerini, Laura (VerfasserIn)
Weitere Verfasser: Amodio, Giada, Bassi, Virginia, Vitale, Serena, Mottola, Ilaria, Di Stefano, Marina, Fanti, Lorella, Sgaramella, Paola, Ziparo, Chiara, Furio, Silvia, Auricchio, Renata, Barera, Graziano, Di Nardo, Giovanni, Troncone, Riccardo, Gianfrani, Carmen, Gregori, Silvia
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Gliadin-specific T cells Interleukin 10 Potential celiac disease T regulatory type 1 Tolerogenic dendritic cells Villous atrophy Gliadin 9007-90-3 mehr... Interleukin-10 130068-27-8 Glutens 8002-80-0 Cytokines
Beschreibung
Zusammenfassung:Copyright © 2023. Published by Elsevier Inc.
Celiac Disease (CD) is a T-cell mediated disorder caused by immune response to gluten, although the mechanisms underlying CD progression are still elusive. We analyzed immune cell composition, plasma cytokines, and gliadin-specific T-cell responses in patients with positive serology and normal intestinal mucosa (potential-CD) or villous atrophy (acute-CD), and after gluten-free diet (GFD). We found: an inflammatory signature and the presence of circulating gliadin-specific IFN-γ+ T cells in CD patients regardless of mucosal damage; an increased frequency of IL-10-secreting dendritic cells (DC-10) in the gut and of circulating gliadin-specific IL-10-secreting T cells in potential-CD; IL-10 inhibition increased IFN-γ secretion by gliadin-specific intestinal T cells from acute- and potential-CD. On GFD, inflammatory cytokines normalized, while IL-10-producing T cells accumulated in the gut. We show that IL-10-producing cells are fundamental in controlling pathological T-cell responses to gluten: DC-10 protect the intestinal mucosa from damage and represent a marker of potential-CD
Beschreibung:Date Completed 19.02.2024
Date Revised 10.04.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2024.109923