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240124s2024 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.3c02838
|2 doi
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|a pubmed25n1224.xml
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|a (DE-627)NLM367557126
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|a (NLM)38265289
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wu, Jing
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Self-Assembled Nanoflowers Realizes Synergistic Sterilization with Photothermal and Chemical Kinetics Therapy
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 13.02.2024
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|a Date Revised 15.02.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Wounds caused by bacterial infections have become a major challenge in the medical field; however, the overuse of antibiotics has led to increased resistance and bioaccumulation. Therefore, it is urgent to develop an antibacterial agent with excellent antibacterial properties and biosafety. Here, we designed an antibacterial platform that combines photothermal and chemical kinetics therapies. Platinum-cobalt (PtCo) bimetallic nanoparticles (NPs) were first prepared, and then PtCoMnO2 nanoflowers were obtained by adding MES buffer solution and KMnO4 to the PtCo bimetallic nanoparticle suspension using ultrasound. When light strikes metal NPs, they can strongly absorb the photon energy, resulting in photothermal properties. In addition, Pt and Co were used as the oxidase mimics, and MnO2 was used as the catalase mimic. In summary, the photothermal capacity of PtCo@MnO2 nanoflowers with rough surfaces can effectively disrupt the permeability of the bacterial cell membranes. Further, by catalyzing H2O2, PtCo@MnO2 nanoflowers can generate large amounts of hydroxyl free radicals, which can damage bacterial cell membranes, proteins, and DNA. In addition, MnO2 can effectively alleviate the hypoxic environment of the bacterially infected areas and activate deep bacteria, thus achieving the goal of complete sterilization. The in vitro and in vivo results showed that PtCo@MnO2 displayed excellent antibacterial properties and good biocompatibility
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Anti-Bacterial Agents
|2 NLM
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|a Hydrogen Peroxide
|2 NLM
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|a BBX060AN9V
|2 NLM
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|a Manganese Compounds
|2 NLM
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|a Oxides
|2 NLM
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|a manganese oxide
|2 NLM
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|a 64J2OA7MH3
|2 NLM
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| 700 |
1 |
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|a Xiang, Shuqing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Ninglin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Mingqian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Jian
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 40(2024), 5 vom: 06. Feb., Seite 2591-2600
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
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|g volume:40
|g year:2024
|g number:5
|g day:06
|g month:02
|g pages:2591-2600
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|u http://dx.doi.org/10.1021/acs.langmuir.3c02838
|3 Volltext
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