The prevalence and incidence of thrombotic primary antiphospholipid syndrome in adults aged 18-49 years A population-based study in a mountain community in northern Italy

The prevalence and incidence of thrombotic primary antiphospholipid syndrome in adults aged 18-49 years : A population-based study in a mountain community in northern Italy

Copyright © 2023. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 260(2024) vom: 01. März, Seite 109905
1. Verfasser: Andreoli, Laura (VerfasserIn)
Weitere Verfasser: Nalli, Cecilia, Raffetti, Elena, Angeli, Fabrizio, Pascariello, Greta, Zentilin, Arianna, Pedersoli, Federica, Gasparotti, Cinzia, Magoni, Michele, Scarcella, Carmelo, Martini, Giuliana, Franceschini, Franco, Donato, Francesco, Tincani, Angela
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Antiphospholipid syndrome Incidence Myocardial infarction Prevalence Stroke Thrombosis
Beschreibung
Zusammenfassung:Copyright © 2023. Published by Elsevier Inc.
OBJECTIVE: To estimate prevalence and incidence of thrombotic Primary Antiphospholipid Syndrome (PAPS) in the general population aged 18-49 years
METHODS: The study was carried out in Valtrompia, a valley in northern Italy, in 2011-2015. The identification of PAPS cases leveraged three integrated sources: 1) Rheumatology Unit at the University Hospital; 2) General Practitioners; 3) hospital discharge codes of patients admitted for thrombotic events
RESULTS: Prevalence and incidence were estimated as 22.9 (95% C.I. 11.4-41.0) and 5.0 (2.6-8.7) cases per 100,000 individuals, respectively. The estimates were 28.3 and 4.8, and 17.2 and 5.1 in males and females, respectively. The type of disease onset was mainly of arterial type in men and venous in women
CONCLUSIONS: Thrombotic PAPS was found to be a rare disease in this population-based study. Prevalence and incidence were not significantly different between males and females aged 18-49 years, but a different type of onset was observed
Beschreibung:Date Completed 19.02.2024
Date Revised 10.04.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2024.109905