Comparing the immune abnormalities in MIS-C to healthy children and those with inflammatory disease reveals distinct inflammatory cytokine production and a monofunctional T cell response

Comparing the immune abnormalities in MIS-C to healthy children and those with inflammatory disease reveals distinct inflammatory cytokine production and a monofunctional T cell response

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 259(2024) vom: 06. Feb., Seite 109877
1. Verfasser: Butters, Claire (VerfasserIn)
Weitere Verfasser: Benede, Ntombi, Moyo-Gwete, Thandeka, Richardson, Simone I, Rohlwink, Ursula, Shey, Muki, Ayres, Frances, Manamela, Nelia P, Makhado, Zanele, Balla, Sashkia R, Madzivhandila, Mashudu, Ngomti, Amkele, Baguma, Richard, Facey-Thomas, Heidi, Spracklen, Timothy F, Day, Jonathan, van der Ross, Hamza, Riou, Catherine, Burgers, Wendy A, Scott, Christiaan, Zühlke, Liesl, Moore, Penny L, Keeton, Roanne S, Webb, Kate
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antibody effector function Inflammatory cytokine profile MIS-C SARS-CoV-2-specific T cells Cytokines Immunoglobulin G Antibodies, Viral
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245 1 0 |a Comparing the immune abnormalities in MIS-C to healthy children and those with inflammatory disease reveals distinct inflammatory cytokine production and a monofunctional T cell response 
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520 |a Multisystem inflammatory syndrome in children (MIS-C) is a severe, hyperinflammatory disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The underlying immune pathology of MIS-C is incompletely understood, with limited data comparing MIS-C to clinically similar paediatric febrile diseases at presentation. SARS-CoV-2-specific T cell responses have not been compared in these groups to assess whether there is a T cell profile unique to MIS-C. In this study, we measured inflammatory cytokine concentration and SARS-CoV-2-specific humoral immunity and T cell responses in children with fever and suspected MIS-C at presentation (n = 83) where MIS-C was ultimately confirmed (n = 58) or another diagnosis was made (n = 25) and healthy children (n = 91). Children with confirmed MIS-C exhibited distinctly elevated serum IL-10, IL-6, and CRP at presentation. No differences were detected in SARS-CoV-2 spike IgG serum concentration, neutralisation capacity, antibody dependant cellular phagocytosis, antibody dependant cellular cytotoxicity or SARS-CoV-2-specific T cell frequency between the groups. Healthy SARS-CoV-2 seropositive children had a higher proportion of polyfunctional SARS-CoV-2-specific CD4+ T cells compared to children with MIS-C and those with other inflammatory or infectious diagnoses, who both presented a largely monofunctional SARS-CoV-2-specific CD4+ T cell profile. Treatment with steroids and/or intravenous immunoglobulins resulted in rapid reduction of inflammatory cytokines but did not affect the SARS-CoV-2-specific IgG or CD4+ T cell responses in MIS-C. In these data, MIS-C had a unique cytokine profile but not a unique SARS-CoV-2 specific humoral or T cell cytokine response 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Antibody effector function 
650 4 |a Inflammatory cytokine profile 
650 4 |a MIS-C 
650 4 |a SARS-CoV-2-specific T cells 
650 7 |a Cytokines  |2 NLM 
650 7 |a Immunoglobulin G  |2 NLM 
650 7 |a Antibodies, Viral  |2 NLM 
700 1 |a Benede, Ntombi  |e verfasserin  |4 aut 
700 1 |a Moyo-Gwete, Thandeka  |e verfasserin  |4 aut 
700 1 |a Richardson, Simone I  |e verfasserin  |4 aut 
700 1 |a Rohlwink, Ursula  |e verfasserin  |4 aut 
700 1 |a Shey, Muki  |e verfasserin  |4 aut 
700 1 |a Ayres, Frances  |e verfasserin  |4 aut 
700 1 |a Manamela, Nelia P  |e verfasserin  |4 aut 
700 1 |a Makhado, Zanele  |e verfasserin  |4 aut 
700 1 |a Balla, Sashkia R  |e verfasserin  |4 aut 
700 1 |a Madzivhandila, Mashudu  |e verfasserin  |4 aut 
700 1 |a Ngomti, Amkele  |e verfasserin  |4 aut 
700 1 |a Baguma, Richard  |e verfasserin  |4 aut 
700 1 |a Facey-Thomas, Heidi  |e verfasserin  |4 aut 
700 1 |a Spracklen, Timothy F  |e verfasserin  |4 aut 
700 1 |a Day, Jonathan  |e verfasserin  |4 aut 
700 1 |a van der Ross, Hamza  |e verfasserin  |4 aut 
700 1 |a Riou, Catherine  |e verfasserin  |4 aut 
700 1 |a Burgers, Wendy A  |e verfasserin  |4 aut 
700 1 |a Scott, Christiaan  |e verfasserin  |4 aut 
700 1 |a Zühlke, Liesl  |e verfasserin  |4 aut 
700 1 |a Moore, Penny L  |e verfasserin  |4 aut 
700 1 |a Keeton, Roanne S  |e verfasserin  |4 aut 
700 1 |a Webb, Kate  |e verfasserin  |4 aut 
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773 1 8 |g volume:259  |g year:2024  |g day:06  |g month:02  |g pages:109877 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2023.109877  |3 Volltext 
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