Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD

Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD

Copyright © 2023. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 255(2023) vom: 01. Okt., Seite 109750
1. Verfasser: Gupta, Prachi Mehrotra (VerfasserIn)
Weitere Verfasser: Balle, Christina, Tharp, Gregory K, Nelson, Sydney A, Gasper, Melanie A, Brown, Bryan, Alisoltani, Arghavan, Onono, Maricianah, Palanee-Phillips, Thesla, Nair, Gonsagrie, Ayele, Hosseana, Noel-Romas, Laura, Passmore, Jo-Ann S, Burgener, Adam D, Heffron, Renee, Jaspan, Heather B, Bosinger, Steven E
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Randomized Controlled Trial Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Contraception Female genital tract Mucosa Randomized clinical trial Reproductive health Transcriptome mehr... Copper 789U1901C5 Levonorgestrel 5W7SIA7YZW Contraceptive Agents
LEADER 01000caa a22002652 4500
001 NLM361584660
003 DE-627
005 20240410232213.0
007 cr uuu---uuuuu
008 231226s2023 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.clim.2023.109750  |2 doi 
028 5 2 |a pubmed24n1371.xml 
035 |a (DE-627)NLM361584660 
035 |a (NLM)37660744 
035 |a (PII)S1521-6616(23)00513-2 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Gupta, Prachi Mehrotra  |e verfasserin  |4 aut 
245 1 0 |a Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD 
264 1 |c 2023 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 16.11.2023 
500 |a Date Revised 10.04.2024 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2023. Published by Elsevier Inc. 
520 |a Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of the effects of the most common contraceptives on the FGT have not been evaluated in a randomized clinical trial setting. Here, we evaluated the effect of three long-acting contraceptive methods: depot medroxyprogesterone acetate(DMPA-IM), levonorgestrel(LNG) implant, and a copper intrauterine device (Cu-IUD), on the endocervical host transcriptome in 188 women from the Evidence for Contraceptive Options and HIV Outcomes Trial (ECHO) trial. Cu-IUD usage showed the most extensive transcriptomic changes, and was associated with inflammatory and anti-viral host responses. DMPA-IM usage was enriched for pathways associated with T cell responses. LNG implant had the mildest effect on endocervical gene expression, and was associated with growth factor signaling. These data provide a mechanistic basis for the diverse influence that varying contraceptives have on the FGT 
650 4 |a Randomized Controlled Trial 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Contraception 
650 4 |a Female genital tract 
650 4 |a Mucosa 
650 4 |a Randomized clinical trial 
650 4 |a Reproductive health 
650 4 |a Transcriptome 
650 7 |a Copper  |2 NLM 
650 7 |a 789U1901C5  |2 NLM 
650 7 |a Levonorgestrel  |2 NLM 
650 7 |a 5W7SIA7YZW  |2 NLM 
650 7 |a Contraceptive Agents  |2 NLM 
700 1 |a Balle, Christina  |e verfasserin  |4 aut 
700 1 |a Tharp, Gregory K  |e verfasserin  |4 aut 
700 1 |a Nelson, Sydney A  |e verfasserin  |4 aut 
700 1 |a Gasper, Melanie A  |e verfasserin  |4 aut 
700 1 |a Brown, Bryan  |e verfasserin  |4 aut 
700 1 |a Alisoltani, Arghavan  |e verfasserin  |4 aut 
700 1 |a Onono, Maricianah  |e verfasserin  |4 aut 
700 1 |a Palanee-Phillips, Thesla  |e verfasserin  |4 aut 
700 1 |a Nair, Gonsagrie  |e verfasserin  |4 aut 
700 1 |a Ayele, Hosseana  |e verfasserin  |4 aut 
700 1 |a Noel-Romas, Laura  |e verfasserin  |4 aut 
700 1 |a Passmore, Jo-Ann S  |e verfasserin  |4 aut 
700 1 |a Burgener, Adam D  |e verfasserin  |4 aut 
700 1 |a Heffron, Renee  |e verfasserin  |4 aut 
700 1 |a Jaspan, Heather B  |e verfasserin  |4 aut 
700 1 |a Bosinger, Steven E  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 255(2023) vom: 01. Okt., Seite 109750  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:255  |g year:2023  |g day:01  |g month:10  |g pages:109750 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2023.109750  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_11 
912 |a GBV_ILN_24 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 255  |j 2023  |b 01  |c 10  |h 109750